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Equity Incentive Plans - Stock options (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		9 Months Ended		12 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016	Dec. 31, 2016
Options
Outstanding balance at the beginning of the period (in shares)			53,228
Granted (in shares)			1,825,858
Exercised (in shares)			(3,506)
Forfeited (in shares)			(12,959)
Outstanding balance at the end of the period (in shares)	1,862,621		1,862,621		53,228
Options exercisable at the end of the period (in shares)	692,103		692,103
Options vested and expected to vest at end of period (in shares)	1,862,621		1,862,621
Weighted Average Exercise Price per Share
Outstanding balance at the beginning of the period (in dollars per share)			$ 4.93
Granted (in dollars per share)			13.81
Exercised (in dollars per share)			5.55
Forfeited (in dollars per share)			5.78
Outstanding balance at the end of the period (in dollars per share)	$ 13.63		13.63		$ 4.93
Exercisable at the end of the period (in dollars per share)	20.01		20.01
Options vested and expected to vest at end of the period (in dollars per share)	$ 13.63		$ 13.63
Weighted Average Remaining Life in Years
Outstanding balance			8 years 7 months 24 days		7 years
Options exercisable at end of period			7 years 6 months 11 days
Options vested and expected to vest at end of the period			8 years 7 months 24 days
Aggregate Intrinsic Value
Outstanding balance	$ 36		$ 36
Options exercisable at the end of the period	35		35
Options vested and expected to vest at end of the period	36		36
Stock-based compensation expense	649	$ 9	$ 4,905	$ 27
Dividend yield (as a percent)			0.00%
Expiration period			10 years
Compensation cost related to the non-vested awards not yet recognized	5,844		$ 5,844
Weighted average period for recognition of compensation cost			2 years 4 months 24 days
Minimum
Aggregate Intrinsic Value
Vesting period			3 years
Maximum
Aggregate Intrinsic Value
Vesting period			4 years
Research and development expense
Aggregate Intrinsic Value
Stock-based compensation expense	42	7	$ 1,758	21
General and administrative expense
Aggregate Intrinsic Value
Stock-based compensation expense	$ 607	$ 2	$ 3,147	$ 6

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Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Period which an employee's right to exercise an award is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Gross number of share options (or share units) granted during the period.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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