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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019
Cash flows from operating activities: |  |
Net loss | $ (27,514) | $ (32,900)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation expense | 34 | 47
Amortization of contract asset | 135 |
Right-of-use asset | 499 | 729
Stock-based compensation expense | 2,572 | 3,732
Foreign currency (gain) loss | (738) | (126)
Change in fair value of restricted stock liability | 45 | 159
Changes in operating assets and liabilities: |  |
Prepaid expenses and other assets | 774 | 302
Deferred tax assets | (36) | (3)
Research and development incentive receivable | 117 | 643
Contract acquisition costs | (270) |
Accounts payable and accrued expenses | (2,601) | 1,084
Deferred revenue | 1,500 |
Lease liability | (474) | (695)
Net cash used in operating activities | (25,957) | (26,902)
Cash flows from investing activities: |  |
Purchases of property and equipment |  | (100)
Proceeds from sale of property and equipment | 25 | 15
Net cash provided by (used in) investing activities | 25 | (85)
Cash flows from financing activities: |  |
Proceeds from issuance of common stock - June 2020 Public Offering | 48,518 |
Proceeds from issuance of common stock |  | 12,331
Proceeds from issuance of common stock from ATM sales |  | 1,923
Proceeds from issuance of common stock in connection with July 2019 Lincoln Park Capital Registered Offering Purchase Agreement, net of issuance costs |  | 1,000
Proceeds from the exercise of common stock warrants | 348 |
Proceeds from the exercise of stock options | 51 |
Payment of deferred offering costs | (1,906) | (437)
Net cash provided by financing activities | 73,997 | 14,817
Effect of exchange rate changes on cash and cash equivalents | 115 | (223)
Net decrease in cash and cash equivalents | 48,180 | (12,393)
Cash and cash equivalents at beginning of year | 3,891 | 16,284
Cash and cash equivalents at end of year | 52,071 | 3,891
Supplemental disclosure of non-cash financing activities: |  |
Reclassification of 2017 Warrants from liability to equity |  | 3,448
Dividend attributable to down round feature of warrants | 303 | 359
Offering costs included in accounts payable and accrued expenses |  | 444
Right-of-use asset recorded upon adoption of ASU 2016-02 |  | 1,755
Lease liability recorded upon adoption of ASU 2016-02 |  | 1,720
Accrued rent reclassified upon adoption of ASU 216-02 |  | 35
Reclassification of deferred offering costs to additional paid-in-capital |  | $ 23
Conversion of Series A convertible preferred stock to prefunded warrants | (8,836) |
Series A Convertible Preferred Stock |  |
Cash flows from financing activities: |  |
Proceeds from issuance of convertible preferred stock | 14,986 |
Supplemental disclosure of non-cash financing activities: |  |
Conversion of Series A convertible preferred stock to prefunded warrants | 8,836 |
Series A & B Convertible Preferred Stock discount - beneficial conversion feature | 5,226 |
Series B Convertible Preferred Stock |  |
Cash flows from financing activities: |  |
Proceeds from issuance of convertible preferred stock | 12,000 |
Supplemental disclosure of non-cash financing activities: |  |
Conversion of Series B convertible preferred stock to common stock | 7,087 |
Series A & B Convertible Preferred Stock discount - beneficial conversion feature | $ 4,173 |

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