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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Cash flows from operating activities:    
Net loss $ (27,514) $ (32,900)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation expense 34 47
Amortization of contract asset 135  
Right-of-use asset 499 729
Stock-based compensation expense 2,572 3,732
Foreign currency (gain) loss (738) (126)
Change in fair value of restricted stock liability 45 159
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 774 302
Deferred tax assets (36) (3)
Research and development incentive receivable 117 643
Contract acquisition costs (270)  
Accounts payable and accrued expenses (2,601) 1,084
Deferred revenue 1,500  
Lease liability (474) (695)
Net cash used in operating activities (25,957) (26,902)
Cash flows from investing activities:    
Purchases of property and equipment   (100)
Proceeds from sale of property and equipment 25 15
Net cash provided by (used in) investing activities 25 (85)
Cash flows from financing activities:    
Proceeds from issuance of common stock - June 2020 Public Offering 48,518  
Proceeds from issuance of common stock   12,331
Proceeds from issuance of common stock from ATM sales   1,923
Proceeds from issuance of common stock in connection with July 2019 Lincoln Park Capital Registered Offering Purchase Agreement, net of issuance costs   1,000
Proceeds from the exercise of common stock warrants 348  
Proceeds from the exercise of stock options 51  
Payment of deferred offering costs (1,906) (437)
Net cash provided by financing activities 73,997 14,817
Effect of exchange rate changes on cash and cash equivalents 115 (223)
Net decrease in cash and cash equivalents 48,180 (12,393)
Cash and cash equivalents at beginning of year 3,891 16,284
Cash and cash equivalents at end of year 52,071 3,891
Supplemental disclosure of non-cash financing activities:    
Reclassification of 2017 Warrants from liability to equity   3,448
Dividend attributable to down round feature of warrants 303 359
Offering costs included in accounts payable and accrued expenses   444
Right-of-use asset recorded upon adoption of ASU 2016-02   1,755
Lease liability recorded upon adoption of ASU 2016-02   1,720
Accrued rent reclassified upon adoption of ASU 216-02   35
Reclassification of deferred offering costs to additional paid-in-capital   $ 23
Conversion of Series A convertible preferred stock to prefunded warrants (8,836)  
Series A Convertible Preferred Stock    
Cash flows from financing activities:    
Proceeds from issuance of convertible preferred stock 14,986  
Supplemental disclosure of non-cash financing activities:    
Conversion of Series A convertible preferred stock to prefunded warrants 8,836  
Series A & B Convertible Preferred Stock discount - beneficial conversion feature 5,226  
Series B Convertible Preferred Stock    
Cash flows from financing activities:    
Proceeds from issuance of convertible preferred stock 12,000  
Supplemental disclosure of non-cash financing activities:    
Conversion of Series B convertible preferred stock to common stock 7,087  
Series A & B Convertible Preferred Stock discount - beneficial conversion feature $ 4,173