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CONSOLIDATED STATEMENT OF CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Series A Convertible Preferred Stock Preferred Stock | Series A Convertible Preferred Stock | Series B Convertible Preferred Stock Preferred Stock | Series B Convertible Preferred Stock | Common Stock. | Additional Paid-in Capital. | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit | Total
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at the beginning of the period (in shares) at Dec. 31, 2019 |  |  |  |  | 24,194,877 |  |  |  |
Increase (Decrease) in Shares Outstanding |  |  |  |  |  |  |  |  |
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts (in shares) | 1,421,801 |  | 1,137,442 |  |  |  |  |  |
Conversion of Series A & B Convertible Preferred Stock dividends to prefunded warrants and common stock (in shares) |  |  |  |  | 156,713 |  |  |  |
Conversion of Series A Convertible Preferred Stock to prefunded warrants (in shares) | (1,421,801) |  |  |  |  |  |  |  |
Conversion of Series B Convertible Preferred Stock to common stock (in shares) |  |  | (1,137,442) |  | 11,374,420 |  |  |  |
Issuance of common stock in connection with Public offering, net of issuance costs (in shares) |  |  |  |  | 23,625,000 |  |  |  |
Issuance of common stock upon exercise of stock options (in shares) |  |  |  |  | 32,778 |  |  |  | 32,778
Issuance of common stock upon exercise of warrant (in shares) |  |  |  |  | 273,954 |  |  |  |
Balance at the end of the period (in shares) at Dec. 31, 2020 |  |  |  |  | 59,657,742 |  |  |  |
Balance at the beginning of the period at Dec. 31, 2019 |  |  |  |  | $ 24 | $ 193,319 | $ 76 | $ (195,168) | $ (1,749)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |
Issuance of Series A & B Convertible Preferred Stock, net of underwriting discounts | $ 14,062 |  | $ 11,260 |  |  |  |  |  |
Series A & B Convertible Preferred Stock discount - beneficial conversion feature | (5,226) | $ 5,226 | (4,173) | $ 4,173 |  | 9,399 |  |  | 9,399
Series A & B Convertible Preferred Stock accrued dividends | 207 |  | 165 |  |  | (372) |  |  | (372)
Conversion of Series A & B Convertible Preferred Stock dividends to prefunded warrants and common stock | (207) |  | (165) |  | 1 | 371 |  |  | 372
Conversion of Series A convertible preferred stock to prefunded warrants | $ (8,836) |  |  |  |  | 8,836 |  |  | 8,836
Conversion of Series B Convertible Preferred Stock to common stock |  |  | $ (7,087) |  | 11 | 7,076 |  |  | 7,087
Issuance of common stock and prefunded warrants in connection with Public Offering, net of issuance cost |  |  |  |  | 24 | 48,252 |  |  | 48,276
Issuance of common stock upon exercise of stock options |  |  |  |  |  | 51 |  |  | 51
Issuance of common stock upon exercise of warrants |  |  |  |  |  | 348 |  |  | 348
Dividend attributable to the down round feature of 2017 Warrants |  |  |  |  |  | 303 |  | (303) | (303)
Foreign currency translation adjustment |  |  |  |  |  |  | (655) |  | (655)
Stock-based compensation |  |  |  |  |  | 2,572 |  |  | 2,572
Net loss |  |  |  |  |  |  |  | (27,514) | (27,514)
Balance at the end of the period at Dec. 31, 2020 |  |  |  |  | $ 60 | 270,155 | (579) | (222,985) | $ 46,651
Increase (Decrease) in Shares Outstanding |  |  |  |  |  |  |  |  |
Issuance of common stock in connection with Public offering, net of issuance costs (in shares) |  |  |  |  | 27,568,072 |  |  |  |
Issuance of common stock upon exercise of stock options (in shares) |  |  |  |  | 2,292 |  |  |  | 2,292
Issuance of common stock upon exercise of warrant (in shares) |  |  |  |  | 530,643 |  |  |  |
Issuance of common stock upon exercise of prefunded warrants (in shares) |  |  |  |  | 559,705 |  |  |  |
Balance at the end of the period (in shares) at Dec. 31, 2021 |  |  |  |  | 88,318,454 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |
Issuance of common stock and prefunded warrants in connection with Public Offering, net of issuance cost |  |  |  |  | $ 27 | 96,801 |  |  | $ 96,828
Issuance of common stock upon exercise of stock options |  |  |  |  |  | 4 |  |  | 4
Issuance of common stock upon exercise of warrants |  |  |  |  |  | 993 |  |  | 993
Issuance of common stock upon exercise of prefunded warrants |  |  |  |  | 1 | (1) |  |  |
Foreign currency translation adjustment |  |  |  |  |  |  | 312 |  | 312
Stock-based compensation |  |  |  |  |  | 3,686 |  |  | 3,686
Net loss |  |  |  |  |  |  |  | (40,587) | (40,587)
Balance at the end of the period at Dec. 31, 2021 |  |  |  |  | $ 88 | $ 371,638 | $ (267) | $ (263,572) | $ 107,887

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