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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities: |  |
Net loss | $ (40,587) | $ (27,514)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation expense | 29 | 34
Amortization of contract asset | 135 | 135
Change in right-of-use asset | 392 | 499
Stock-based compensation expense | 3,686 | 2,572
Foreign currency (gain) loss | 379 | (738)
Change in fair value of restricted stock liability | (204) | 45
Changes in operating assets and liabilities: |  |
Prepaid expenses and other assets | (639) | 774
Deferred tax assets | 11 | (36)
Research and development incentive receivable | (1,159) | 117
Contract acquisition costs |  | (270)
Deferred offering costs | 209 |
Accounts payable and accrued expenses | 3,900 | (2,601)
Deferred revenue | (1,500) | 1,500
Lease liability | (406) | (474)
Other assets | 597 |
Net cash used in operating activities | (35,157) | (25,957)
Cash flows from investing activities: |  |
Proceeds from sale of property and equipment |  | 25
Net cash provided by investing activities |  | 25
Cash flows from financing activities: |  |
Proceeds from issuance of common stock and prefunded warrants, net of offering costs - September 2021 Public Offering | 97,222 |
Proceeds from issuance of common stock - June 2020 Public Offering |  | 48,518
Proceeds from the exercise of common stock warrants | 993 | 348
Proceeds from the exercise of stock options | 4 | 51
Payment of deferred offering costs | (184) | (1,906)
Net cash provided by financing activities | 98,035 | 73,997
Effect of exchange rate changes on cash and cash equivalents | (33) | 115
Net increase in cash and cash equivalents | 62,845 | 48,180
Cash and cash equivalents at beginning of year | 52,071 | 3,891
Cash and cash equivalents at end of year | 114,916 | 52,071
Supplemental disclosure of non-cash financing activities: |  |
Offering costs in accounts payable and accrued expense - September 2021 Public Offering | 210 |
Remeasurement of right-of-use asset and lease liability | $ 323 |
Dividend attributable to down round feature of warrants |  | 303
Beneficial conversion feature from Series convertible preferred stock |  | 9,399
Series A Convertible Preferred Stock |  |
Cash flows from financing activities: |  |
Proceeds from the issuance of Series convertible preferred stock |  | 14,986
Supplemental disclosure of non-cash financing activities: |  |
Conversion of Series A convertible preferred stock to prefunded warrants |  | 8,836
Beneficial conversion feature from Series convertible preferred stock |  | 5,226
Series B Convertible Preferred Stock |  |
Cash flows from financing activities: |  |
Proceeds from the issuance of Series convertible preferred stock |  | 12,000
Supplemental disclosure of non-cash financing activities: |  |
Conversion of Series B convertible preferred stock to common stock |  | 7,087
Beneficial conversion feature from Series convertible preferred stock |  | $ 4,173

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