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Income Taxes - Components of Deferred Tax Assets (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Deferred Tax Assets |  |
Accrued expenses | $ 729 | $ 455
License Fees | 1,004 | 1,168
Stock Options | 4,671 | 3,759
Other | 212 | 228
State net operating loss carryforwards | 11,246 | 8,959
Federal net operating loss carryforwards | 41,207 | 33,711
Total deferred tax assets | 66,241 | 53,848
Valuation allowance | (66,082) | (53,669)
Net deferred tax asset (liability) | 159 | 179
Federal |  |
Deferred Tax Assets |  |
Research tax credits | 6,166 | 4,943
State |  |
Deferred Tax Assets |  |
Research tax credits | $ 1,006 | $ 625

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