XML 36 R27.htm IDEA: XBRL DOCUMENT
v3.24.3

Equity Incentive Plans (Tables) | 9 Months Ended
--- | ---
Sep. 30, 2024
Equity Incentive Plans |
Schedule of stock option activity under the Equity Plans | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ | ​ |  | Weighted |  | ​ | ​ |  | ​
​ | ​ | ​ | ​ |  | Average |  | Weighted | ​ |  | Aggregate
​ | ​ | ​ | ​ |  | Exercise Price |  | Average Remaining | ​ |  | Intrinsic
​ |  | Options | ​ |  | Per Share |  | Life in Years | ​ |  | Value
Outstanding at December 31, 2023 |  | 3,384,366 | ​ | $ | 13.97 |  | 8.40 | ​ | $ | 3,431
Granted | ​ | 1,727,500 | ​ | $ | 2.67 | ​ | ​ | ​ | ​ | ​
Exercised | ​ | (10,557) | ​ | $ | 2.77 | ​ | ​ | ​ | ​ | ​
Forfeited |  | (254,674) | ​ | $ | 5.69 |  | ​ | ​ | ​ | ​
Outstanding at September 30, 2024 |  | 4,846,635 | ​ | $ | 10.40 |  | 8.24 | ​ | $ | 527
Options exercisable at September 30, 2024 |  | 2,396,563 | ​ | $ | 17.90 |  | 7.40 | ​ | ​ | ​
Options vested and expected to vest at September 30, 2024 |  | 4,846,635 | ​ | $ | 10.40 |  | 8.24 | ​ | $ | 527
Schedule of assumptions used to determine grant-date fair value of stock options | ​
​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Nine Months Ended September 30, | ​
​ |  | 2024 |  | 2023 | ​
​ | ​ | ​ | ​ | ​ | ​
Expected volatility | ​ | 92.99 | % | 90.37 | %
Weighted average risk-free interest rate | ​ | 3.98 | % | 4.05 | %
Expected dividend yield | ​ | 0.00 | % | 0.00 | %
Expected term (in years) | ​ | 6.46 | ​ | 6.48 | ​
Schedule of RSU activity under the 2016 Plan | ​
​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | Weighted
​ | ​ | ​ | ​ | Average Grant
​ |  | Number of Shares |  | Date Fair Value
Outstanding at December 31, 2023 |  | 262,500 | ​ | $ | 19.97
Vested | ​ | (27,500) | ​ | $ | 25.70
Forfeited | ​ | (7,500) | ​ | $ | 19.40
Outstanding at September 30, 2024 |  | 227,500 | ​ | $ | 19.29
Schedule of recognized stock-based compensation expense related to the issuance of stock option awards and RSUs to employees and non-employees in the condensed consolidated statements of operations | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Three Months Ended September 30, | ​ | Nine Months Ended September 30,
​ |  | 2024 |  | 2023 |  | 2024 |  | 2023
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Research and development |  | $ | 720 | ​ | $ | 737 | ​ | $ | 2,076 | ​ | $ | 2,086
General and administrative |  | ​ | 619 | ​ |  | 563 | ​ | ​ | 1,881 | ​ |  | 1,789
Total | ​ | $ | 1,339 | ​ | $ | 1,300 | ​ | $ | 3,957 | ​ | $ | 3,875
​

X
- References No definition available. + Details
Name: | us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
Name: | us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
Name: | us-gaap_ScheduleOfShareBasedCompensationRestrictedStockUnitsAwardActivityTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
Name: | us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
Name: | us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration