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Note 10 - Related Party Transactions (Details Textual) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended
Aug. 31, 2016
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross       1,698,452    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance   $ 2.80   $ 2.80   $ 2.96
Allocated Share-based Compensation Expense, Total   $ 730,000 $ 701,000 $ 2,083,000 $ 1,999,000  
OPKO [Member]            
Related Party, Ownership Percentage 5.00%          
OPKO [Member] | Consulting Services [Member]            
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross 418,977          
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period 4 years          
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance $ 1.80          
Allocated Share-based Compensation Expense, Total       121,000 $ 432,000  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested Grant Date Fair Value   $ 5,300,000   $ 5,300,000    
Consulting Agreement, Term 4 years          
Consulting Agreement, Term, Length of Automatic Renewal Periods 1 year          
Chairman and Chief Executive Officer of OPKO [Member]            
Related Party, Ownership Percentage 5.00%