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Note 17 - Related Party Transactions (Details Textual) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Aug. 31, 2016 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  | 1,698,452 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance |  | $ 2.80 | $ 2.96 |
Share-based Compensation, Total |  | $ 2,774,000 | $ 2,707,000 | $ 942,000
OPKO [Member] | Consulting Services [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross | 418,977 |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period | 4 years |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance | $ 1.80 |  |  |
Share-based Compensation, Total |  | $ 142,000 | 480,000 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested Grant Date Fair Value |  |  | $ 5,300,000 |
Consulting Agreement, Term | 4 years |  |  |
Consulting Agreement, Term, Length of Automatic Renewal Periods | 1 year |  |  |
Chairman and Chief Executive Officer of OPKO [Member] |  |  |  |
Related Party, Ownership Percentage | 5.00% |  |  |

X
- Definition Represents the term of a consulting agreement. + References No definition available. + Details
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- Definition Represents the length of time of each of the automatic renewal periods for the term of a consulting agreement. + References No definition available. + Details
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- Definition Represents the percentage of the entity that is owned by a specified related party. + References No definition available. + Details
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- Definition Grant-date fair value of non-vested options outstanding. + References No definition available. + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
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- Definition Period which an employee's right to exercise an award is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(1) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 + Details
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- Definition Gross number of share options (or share units) granted during the period. + References No definition available. + Details
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- Definition Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(i) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 + Details
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