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Note 14 - Income Taxes - Effective Income Tax Reconciliation (Details) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Tax at federal statutory rate | $ (2,937,000) | $ (4,185,000) | $ (3,505,000)
State, net of federal benefit | (455,000) | (1,238,000) | (315,000)
Research and development credit | (236,000) | (135,000) | (89,000)
Stock-based compensation | 440,000 | 344,000 | 136,000
Nondeductible interest |  |  | 590,000
Warrant and derivative revaluation |  |  | 328,000
Change in Federal tax rate |  | 8,172,000 |
Other | 22,000 | 7,000 | 94,000
Change in valuation allowance | 3,166,000 | (2,965,000) | 2,761,000
Total provision for income taxes | $ 0 | $ 0 | $ 0

X
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to warrant and derivative revaluation. + References No definition available. + Details
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