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Note 11 - Share-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2018
Notes Tables |
Schedule of Share-based Compensation, Expense [Table Text Block] |
|  | Years ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2015 |
Cost of goods sold |  | $ | 143 |  |  | $ | 140 |  |  | $ | 14 |
Research and development |  |  | 953 |  |  |  | 678 |  |  |  | 127 |
Selling, general and administrative |  |  | 1,678 |  |  |  | 1,889 |  |  |  | 801 |
Share-based compensation expense |  | $ | 2,774 |  |  | $ | 2,707 |  |  | $ | 942 |
Share-based Compensation, Stock Options, Activity [Table Text Block] |
|  | Options outstanding |  |  |  |  |  |  |  |  |
|  | Number of shares |  |  | Weighted average exercise price |  |  | Weighted average remaining contractual term (years) |  |  | Aggregate intrisinsic value (in thousands) |
Balance, December 31, 2017 |  |  | 4,213,100 |  |  | $ | 2.96 |  |  |  | 8.1 |  |  | $ | 1,890 |
Stock options granted |  |  | 1,698,452 |  |  |  | 2.41 |  |  |  |  |  |  |  |  |
Stock options exercised |  |  | (2,488 | ) |  |  | 1.80 |  |  |  |  |  |  |  |  |
Stock options canceled |  |  | (431,700 | ) |  |  | 2.92 |  |  |  |  |  |  |  |  |
Balance, December 31, 2018 |  |  | 5,477,364 |  |  | $ | 2.80 |  |  |  | 7.8 |  |  | $ | - |
Exercisable and vested, December 31, 2018 |  |  | 2,346,990 |  |  | $ | 2.72 |  |  |  | 6.9 |  |  | $ | - |
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] |
|  |  |  |  |  | Weighted |
|  |  |  |  |  | average |
|  |  |  |  |  | grant date |
|  | Number of |  |  | fair value |
|  | shares |  |  | per share |
Balance, December 31, 2017 |  |  | 97,996 |  |  | $ | 8.71 |
RSUs granted |  |  | 226,471 |  |  | $ | 1.36 |
RSUs vested |  |  | (57,108 | ) |  | $ | 7.03 |
RSUs forfeited |  |  | - |  |  |  | — |
Balance, December 31, 2018 |  |  | 267,359 |  |  | $ | 2.84 |
Non-employee Stock Options [Member] |
Notes Tables |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Years ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Risk-free interest rate |  | 2.80 | - | 2.95% |  |  | 2.25 | - | 2.40% |  |  | 1.60 | - | 2.42% |
Volatility |  | 78 | - | 85% |  |  | 81 | - | 87% |  |  | 89 | - | 91% |
Dividend yield |  | None |  |  | None |  |  | None |
Expected term (in years) |  | 7.6 | - | 8.8 |  |  | 8.6 | - | 9.8 |  |  | 9.6 | - | 9.9 |
Employee Stock Option [Member] |
Notes Tables |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Years ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Risk-free interest rate |  | 2.66 | - | 2.89% |  |  | 1.76 | - | 2.25% |  |  | 1.28 | - | 1.58% |
Volatility |  | 81 | - | 83% |  |  | 81 | - | 89% |  |  |  | 88% |  |
Dividend yield |  | None |  |  | None |  |  | None |
Expected term (in years) |  |  | 6.25 |  |  |  | 5.00 | - | 6.25 |  |  |  | 6.25 |  |

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