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Note 6 - Property and Equipment, Net (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
December 31,
 
   
2018
   
2017
 
Computer equipment and software
  $
119
     
106
 
Laboratory and manufacturing equipment
   
481
     
447
 
Furniture and fixtures
   
55
     
48
 
Leasehold improvements
   
332
     
326
 
Construction in progress
   
3
     
 
Property and equipment, gross
   
990
     
927
 
Less accumulated depreciation
   
(845
)    
(758
)
Property and equipment, net
  $
145
     
169