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Note 10 - Share-based Compensation - Share-based Compensation Expense (Details) - USD ($) |  | 12 Months Ended
--- | --- | ---
Jan. 29, 2020 | Dec. 31, 2021 | Dec. 31, 2020
Share-based compensation expense | $ 412,000 | $ 1,661,000 | $ 2,952,000
Research and Development Expense [Member] |  |  |
Share-based compensation expense |  | 795,000 | 1,369,000
Selling, General and Administrative Expenses [Member] |  |  |
Share-based compensation expense |  | $ 866,000 | $ 1,583,000

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