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Note 9 - Stockholders' Equity (Details Textual) - USD ($) |  |  |  |  |  |  |  | 12 Months Ended |
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Mar. 29, 2021 | Dec. 18, 2020 | Dec. 16, 2020 | Jun. 19, 2020 | Jun. 17, 2020 | Jun. 08, 2020 | Sep. 04, 2019 | Dec. 31, 2021 | Dec. 31, 2020 | Aug. 06, 2019
Common Stock, Par or Stated Value Per Share (in dollars per share) |  |  |  |  |  |  |  | $ 0.001 | $ 0.001 |
Stock Issued During Period, Value, New Issues |  |  |  |  |  |  |  | $ 1,942,000 |  |
Proceeds from Issuance of Common Stock |  |  |  |  |  |  |  | 2,001,000 | $ 0 |
Stock Issued During Period, Value, Issued for Services |  |  |  |  |  |  |  |  | 148,000 |
Two Former Board Members [Member] |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Issued for Services (in shares) |  |  |  |  |  | 29,625 |  |  |  |
Stock Issued During Period, Value, Issued for Services |  |  |  |  |  | $ 148,000 |  |  |  |
Underwriters [Member] |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  |  |  |  |  | 75,000 |  |  |
The $10.5 Million Registered Direct Offering [Member] |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  | 2,038,836 |  |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share (in dollars per share) |  | $ 0.001 |  |  |  |  |  |  |  |
Shares Issued, Price Per Share (in dollars per share) |  | $ 5.15 |  |  |  |  |  |  |  |
Stock Issued During Period, Value, New Issues |  | $ 10,500,000 |  |  |  |  |  |  | 9,765,000 |
Placement Agent Fee |  | 7.00% |  |  |  |  |  |  |  |
Proceeds from Issuance of Common Stock |  | $ 9,800,000 |  |  |  |  |  | 0 | 10,500,000 |
The $8.5 Million Registered Direct Offering [Member] |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  | 1,789,474 |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share (in dollars per share) |  |  | $ 0.001 |  |  |  |  |  |  |
Shares Issued, Price Per Share (in dollars per share) |  |  | $ 4.75 |  |  |  |  |  |  |
Stock Issued During Period, Value, New Issues |  |  | $ 8,500,000 |  |  |  |  |  | 7,827,000 |
Placement Agent Fee |  |  | 7.00% |  |  |  |  |  |  |
Proceeds from Issuance of Common Stock |  |  | $ 7,800,000 |  |  |  |  | 0 | 8,500,000 |
Placement Agent Maximum Expenses Reimbursement Amount |  |  | $ 40,000 |  |  |  |  |  |  |
Public Offering [Member] |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  |  | 4,762,000 |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share (in dollars per share) |  |  |  | $ 0.001 |  |  |  |  |  |
Shares Issued, Price Per Share (in dollars per share) |  |  |  | $ 2.10 |  |  |  |  |  |
Stock Issued During Period, Value, New Issues |  |  |  |  |  |  |  |  | 10,273,000 |
Proceeds from Issuance of Common Stock |  |  |  | $ 10,300,000 |  |  |  | $ 0 | $ 11,500,000 |
Underwriters, Additional Common Shares Authorized to Purchase (in shares) |  |  |  |  | 714,190 |  |  |  |  |
Purchase Agreement with Lincoln Park [Member] |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) | 373,832 |  |  |  |  |  |  | 0 |  |
Shares Issued, Price Per Share (in dollars per share) | $ 5.35 |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Common Stock | $ 2,000,000 |  |  |  |  |  |  |  |  |
Sale of Stock, Aggregate Value, Maximum | $ 20,000,000 |  |  |  |  |  |  |  |  |
Stock Issuable, Commitment Shares on Pro Rata Basis (in shares) | 50,000 |  |  |  |  |  |  |  |  |
Stock Issued During the Period, Shares, Commission Fees (in shares) | 80,000 |  |  |  |  |  |  |  |  |
Stock Issued During the Period, Commitment Shares Issued on Pro Rata Basis (in shares) | 5,000 |  |  |  |  |  |  |  |  |
Conditional Issuance, Maximum Number of Shares Allowed to be Purchased (in shares) | 100,000 |  |  |  |  |  |  |  |  |
Stock Purchase Agreement Accelerated Purchase, Maximum, Percent of Shares Purchased on the Same Trading Day | 300.00% |  |  |  |  |  |  |  |  |
Stock Purchase Agreement Accelerated Purchase, Maximum, Percent of Total Common Shares Traded During Specified Period | 30.00% |  |  |  |  |  |  |  |  |
Maximum Number of Shares Allowed to be Issued Including Commitment Shares (in shares) | 3,266,177 |  |  |  |  |  |  |  |  |
Percentage of Common Stock Outstanding | 19.99% |  |  |  |  |  |  |  |  |
Private Placement Unit [Member] |  |  |  |  |  |  |  |  |  |
Number of Common Stock in Each Unit (in shares) |  |  |  |  |  |  |  |  |  | 1

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