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Note 10 - Share-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2021
Notes Tables |
Schedule of Share-based Compensation, Expense [Table Text Block] |
|  | Years ended |
|  | December 31, |
|  | 2021 |  |  | 2020 |
Research and development |  | $ | 795 |  |  | $ | 1,369 |
Selling, general and administrative |  |  | 866 |  |  |  | 1,583 |
Total share-based compensation |  | $ | 1,661 |  |  | $ | 2,952 |
Share-based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Options outstanding |  |  |  |  |  |  |  |  |
|  | Number of shares |  |  | Weighted average exercise price |  |  | Weighted average remaining contractual term (years) |  |  | Aggregate intrinsic value (in thousands) |
Balance, December 31, 2020 |  |  | 1,114,306 |  |  | $ | 5.89 |  |  |  | 7.5 |  |  | $ | 177.1 |
Stock options granted |  |  | 772,435 |  |  |  | 3.56 |  |  |  |  |  |  |  |  |
Stock options exercised |  |  | (1,580 | ) |  |  | 2.49 |  |  |  |  |  |  |  |  |
Stock options forfeited |  |  | (235,350 | ) |  |  | 4.49 |  |  |  |  |  |  |  |  |
Stock options expired |  |  | (125 | ) |  |  | 5.32 |  |  |  |  |  |  |  |  |
Balance, December 31, 2021 |  |  | 1,649,686 |  |  | $ | 5.00 |  |  |  | 7.6 |  |  | $ | — |
Exercisable, December 31, 2021 |  |  | 762,867 |  |  | $ | 6.62 |  |  |  | 6.0 |  |  | $ | — |
Options vested and expected to vest |  |  | 1,649,686 |  |  | $ | 5.00 |  |  |  | 7.6 |  |  | $ | — |
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] |
|  |  |  |  |  | Weighted |
|  |  |  |  |  | average |
|  |  |  |  |  | grant date |
|  | Number of |  |  | fair value |
|  | shares |  |  | per share |
Balance, December 31, 2020 |  |  | 224,311 |  |  | $ | 4.12 |
RSUs granted |  |  | 131,375 |  |  |  | 3.61 |
RSUs released |  |  | (118,472 | ) |  |  | 3.73 |
RSUs forfeited |  |  | (36,943 | ) |  |  | 3.49 |
Balance, December 31, 2021 |  |  | 200,271 |  |  | $ | 4.13 |
Share-based Payment Arrangement, Option [Member] |
Notes Tables |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Years ended |
|  | December 31, |
|  | 2021 |  |  | 2020 |
Risk-free interest rate |  | 0.6 | - | 1.6% |  |  | 0.4 | - | 1.6% |
Volatility |  | 110 | - | 120% |  |  | 107 | - | 112% |
Dividend yield |  | None |  |  | None |
Expected term (in years) |  | 6.25 | - | 10.0 |  |  | 6.25 | - | 10.0 |

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