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Note 9 - Share-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2023
Notes Tables |
Schedule of Share-based Compensation, Expense [Table Text Block] |
|  | Years ended |
|  | December 31, |
|  | 2023 |  |  | 2022 |
Research and development |  | $ | 465 |  |  | $ | 528 |
Selling, general and administrative |  |  | 565 |  |  |  | 655 |
Total share-based compensation |  | $ | 1,030 |  |  | $ | 1,183 |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Options outstanding |  |  |  |  |  |  |  |  |
|  | Number of shares |  |  | Weighted average exercise price |  |  | Weighted average remaining contractual term (years) |  |  | Aggregate intrinsic value (in thousands) |
Balance, December 31, 2022 |  |  | 2,182,708 |  |  | $ | 4.04 |  |  |  | 7.5 |  |  | $ | 343 |
Stock options granted |  |  | 708,284 |  |  |  | 1.39 |  |  |  |  |  |  |  |  |
Stock options exercised |  |  | (199 | ) |  |  | 1.49 |  |  |  |  |  |  |  |  |
Stock options forfeited |  |  | (397,677 | ) |  |  | 2.42 |  |  |  |  |  |  |  |  |
Stock options expired |  |  | (6,349 | ) |  |  | 16.09 |  |  |  |  |  |  |  |  |
Balance, December 31, 2023 |  |  | 2,486,767 |  |  | $ | 3.51 |  |  |  | 6.8 |  |  | $ | 43 |
Exercisable, December 31, 2023 |  |  | 1,552,294 |  |  | $ | 4.56 |  |  |  | 5.5 |  |  | $ | — |
Options vested and expected to vest |  |  | 2,486,767 |  |  | $ | 3.51 |  |  |  | 6.8 |  |  | $ | 43 |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Years ended |
|  | December 31, |
|  | 2023 |  |  | 2022 |
Risk-free interest rate |  | 3.7 | - | 4.9% |  |  | 1.8 | - | 3.8% |
Volatility |  | 110 | - | 120% |  |  | 116 | - | 122% |
Dividend yield |  | None |  |  | None |
Expected term (in years) |  | 6.25 | - | 10.0 |  |  | 6.25 | - | 10.0 |
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] |
|  |  |  |  |  | Weighted |
|  |  |  |  |  | average |
|  |  |  |  |  | grant date |
|  | Number of |  |  | fair value |
|  | shares |  |  | per share |
Balance, December 31, 2022 |  |  | 21,526 |  |  | $ | 4.33 |
RSUs granted |  |  | 331,552 |  |  |  | 1.70 |
RSUs released |  |  | (241,197 | ) |  |  | 1.93 |
RSUs forfeited |  |  | (111,881 | ) |  |  | 1.70 |
Balance, December 31, 2023 |  |  | — |  |  | $ | n/a |

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