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Note 9 - Share-based Compensation (Tables)

12 Months Ended

Dec. 31, 2023

Notes Tables

Schedule of Share-based Compensation, Expense [Table Text Block]

		Years ended
		December 31,
		2023				2022
Research and development		$	465			$	528
Selling, general and administrative			565				655
Total share-based compensation		$	1,030			$	1,183

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

		Options outstanding
		Number of shares				Weighted average exercise price				Weighted average remaining contractual term (years)				Aggregate intrinsic value (in thousands)
Balance, December 31, 2022			2,182,708			$	4.04				7.5			$	343
Stock options granted			708,284				1.39
Stock options exercised			(199	)			1.49
Stock options forfeited			(397,677	)			2.42
Stock options expired			(6,349	)			16.09
Balance, December 31, 2023			2,486,767			$	3.51				6.8			$	43
Exercisable, December 31, 2023			1,552,294			$	4.56				5.5			$	—
Options vested and expected to vest			2,486,767			$	3.51				6.8			$	43

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		Years ended
		December 31,
		2023					2022
Risk-free interest rate		3.7	-	4.9%			1.8	-	3.8%
Volatility		110	-	120%			116	-	122%
Dividend yield		None					None
Expected term (in years)		6.25	-	10.0			6.25	-	10.0

Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]

						Weighted
						average
						grant date
		Number of				fair value
		shares				per share
Balance, December 31, 2022			21,526			$	4.33
RSUs granted			331,552				1.70
RSUs released			(241,197	)			1.93
RSUs forfeited			(111,881	)			1.70
Balance, December 31, 2023			—			$	n/a

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