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Note 8 - Share-based Compensation (Tables)
9 Months Ended
Sep. 30, 2024
Notes Tables  
Schedule of Share-based Compensation, Expense [Table Text Block]
   

Three months ended

   

Nine months ended

 
   

September 30,

   

September 30,

 
   

2024

   

2023

   

2024

   

2023

 

Research and development

  $ 98     $ 118     $ 315     $ 391  

Selling, general and administrative

    79       133       250       455  

Total share-based compensation

  $ 177     $ 251     $ 565     $ 846  
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
   

Number of

shares

   

Weighted

average exercise

price

   

Weighted

average

remaining

contractual

term (years)

   

Aggregate intrinsic

value
(in thousands)

 
                                 

Balance, December 31, 2023

    165,784     $ 52.67       6.8     $ 43  

Stock options forfeited

    (3,177 )     33.97                  

Stock options expired

    (9,317 )     63.09                  

Balance, September 30, 2024

    153,290     $ 52.43       6.5     $  

Exercisable, September 30, 2024

    109,830     $ 63.83       5.8     $