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Note 9 - Share-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2024
Notes Tables |
Schedule of Share-based Compensation, Expense [Table Text Block] |
|  | Years ended |
|  | December 31, |
|  | 2024 |  |  | 2023 |
Research and development |  | $ | 413 |  |  | $ | 465 |
Selling, general and administrative |  |  | 328 |  |  |  | 565 |
Total share-based compensation |  | $ | 741 |  |  | $ | 1,030 |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Number of shares |  |  | Weighted average exercise price |  |  | Weighted average remaining contractual term (years) |  |  | Aggregate intrinsic value (in thousands) |
Balance, December 31, 2022 |  |  | 145,513 |  |  | $ | 60.60 |  |  |  | 7.5 |  |  |  |  |
Stock options granted |  |  | 47,219 |  |  |  | 20.85 |  |  |  |  |  |  |  |  |
Stock options exercised |  |  | (13 | ) |  |  | 22.35 |  |  |  |  |  |  |  |  |
Stock options forfeited |  |  | (26,512 | ) |  |  | 36.30 |  |  |  |  |  |  |  |  |
Stock options expired |  |  | (423 | ) |  |  | 241.35 |  |  |  |  |  |  |  |  |
Balance, December 31, 2023 |  |  | 165,784 |  |  | $ | 52.67 |  |  |  | 6.8 |  |  |  |  |
Stock options granted |  |  | 14,974 |  |  |  | 2.65 |  |  |  |  |  |  |  |  |
Stock options forfeited |  |  | (3,177 | ) |  |  | 33.97 |  |  |  |  |  |  |  |  |
Stock options expired |  |  | (9,397 | ) |  |  | 63.51 |  |  |  |  |  |  |  |  |
Balance, December 31, 2024 |  |  | 168,184 |  |  | $ | 47.97 |  |  |  | 6.6 |  |  | $ | — |
Exercisable, December 31, 2024 |  |  | 121,530 |  |  | $ | 59.49 |  |  |  | 5.8 |  |  | $ | — |
Options vested and expected to vest |  |  | 168,184 |  |  | $ | 47.97 |  |  |  | 6.6 |  |  | $ | — |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Years ended |
|  | December 31, |
|  | 2024 |  |  | 2023 |
Risk-free interest rate |  |  | 3.9 | % |  | 3.7 | - | 4.9 | %
Volatility |  |  | 125 | % |  | 110 | - | 120 | %
Dividend yield |  | None |  |  | None |
Expected term (in years) |  |  | 6.25 |  |  | 6.25 | - | 10.0 |
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] |
|  |  |  |  |  | Weighted |
|  |  |  |  |  | average |
|  |  |  |  |  | grant date |
|  | Number of |  |  | fair value |
|  | shares |  |  | per share |
Balance, December 31, 2022 |  |  | 1,435 |  |  | $ | 64.95 |
RSUs granted |  |  | 22,104 |  |  |  | 25.50 |
RSUs RSUs vested and settled |  |  | (16,080 | ) |  |  | 28.95 |
RSUs forfeited |  |  | (7,459 | ) |  |  | 25.50 |
Balance, December 31, 2023 |  |  | — |  |  | $ | n/a |
RSUs granted |  |  | 113,427 |  |  |  | 2.65 |
RSUs released |  |  | (60,409 | ) |  |  | 2.65 |
RSUs forfeited |  |  | (53,018 | ) |  |  | 2.65 |
Balance, December 31, 2024 |  |  | — |  |  | $ | n/a |

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