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Note 9 - Share-based Compensation - Stock Option Activity (Details) - USD ($)
$ / shares in Units, $ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Stock options outstanding, options (in shares) 165,784 145,513  
Balance, weighted average exercise price, beginning of period (in dollars per share) $ 52.67 $ 60.6  
Stock options outstanding, weighted average remaining contractual term (Year) 6 years 7 months 6 days 6 years 9 months 18 days 7 years 6 months
Stock options granted, options (in shares) 14,974 47,219  
Stock options granted, weighted average exercise price (in dollars per share) $ 2.65 $ 20.85  
Stock options exercised, options (in shares)   (13)  
Stock options exercised, weighted average exercise price (in dollars per share)   $ 22.35  
Stock options forfeited, options (in shares) (3,177) (26,512)  
Stock options forfeited, weighted average exercise price (in dollars per share) $ 33.97 $ 36.3  
Stock options expired, options (in shares) (9,397) (423)  
Stock options expired, weighted average exercise price (in dollars per share) $ 63.51 $ 241.35  
Stock options outstanding, options (in shares) 168,184 165,784 145,513
Balance, weighted average exercise price, end of period (in dollars per share) $ 47.97 $ 52.67 $ 60.6
Balance, aggregate intrinsic value $ 0    
Exercisable, options (in shares) 121,530    
Exercisable, weighted average exercise price (in dollars per share) $ 59.49    
Exercisable, term (Year) 5 years 9 months 18 days    
Exercisable, aggregate intrinsic value $ 0    
Options vested and expected to vest, options (in shares) 168,184    
Options vested and expected to vest, weighted average exercise price (in dollars per share) $ 47.97    
Options vested and expected to vest, term (Year) 6 years 7 months 6 days    
Options vested and expected to vest, aggregate intrinsic value $ 0