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Note 8 - Share-based Compensation (Tables)
3 Months Ended
Mar. 31, 2025
Notes Tables  
Schedule of Share-based Compensation, Expense [Table Text Block]
   

Three months ended

 
   

March 31,

 
   

2025

   

2024

 

Research and development

  $ 95     $ 115  

Selling, general and administrative

    75       89  

Total share-based compensation

  $ 170     $ 204  
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
   

Number of

shares

   

Weighted

average exercise

price

   

Weighted

average

remaining

contractual

term (years)

   

Aggregate

intrinsic value
(in thousands)

 
                                 

Balance, December 31, 2024

    168,184     $ 47.97       6.6     $  

Balance, March 31, 2025

    168,184     $ 47.97       6.3     $  

Exercisable, March 31, 2025

    127,826     $ 58.07       5.7     $