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Note 8 - Share-based Compensation (Tables)
3 Months Ended
Mar. 31, 2026
Notes Tables  
Schedule of Share-based Compensation, Expense [Table Text Block]
   

Three months ended

 
   

March 31,

 
   

2026

   

2025

 

Research and development

  $ 55     $ 95  

Selling, general and administrative

    58       75  

Total share-based compensation

  $ 113     $ 170  
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
   

Number of

shares

   

Weighted

average exercise

price

   

Weighted

average

remaining

contractual

term (years)

   

Aggregate

intrinsic value
(in thousands)

 
                                 

Outstanding, December 31, 2025

    485,203     $ 17.19       8.4     $  

Stock options granted

    30,000       1.29                  

Stock options forfeited

    (10,193 )     9.94                  

Outstanding, March 31, 2026

    505,010     $ 16.39       8.3     $  

Exercisable, March 31, 2026

    157,036     $ 48.34       5.3     $