<SEC-DOCUMENT>0000899243-18-025642.txt : 20181001
<SEC-HEADER>0000899243-18-025642.hdr.sgml : 20181001
<ACCEPTANCE-DATETIME>20181001141417
ACCESSION NUMBER:		0000899243-18-025642
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20180927
FILED AS OF DATE:		20181001
DATE AS OF CHANGE:		20181001

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Index Venture Associates III Ltd
		CENTRAL INDEX KEY:			0001503683
		STATE OF INCORPORATION:			Y9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36517
		FILM NUMBER:		181096993

	BUSINESS ADDRESS:	
		STREET 1:		NO. 1 SEATON PLACE
		CITY:			ST. HELIER, CHANNEL ISL.
		STATE:			Y9
		ZIP:			JE4 8YJ
		BUSINESS PHONE:		441534605643

	MAIL ADDRESS:	
		STREET 1:		NO. 1 SEATON PLACE
		CITY:			ST. HELIER, CHANNEL ISL.
		STATE:			Y9
		ZIP:			JE4 8YJ

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Index Venture Associates IV Ltd
		CENTRAL INDEX KEY:			0001447962
		STATE OF INCORPORATION:			Y9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36517
		FILM NUMBER:		181096994

	BUSINESS ADDRESS:	
		STREET 1:		44 ESPLANADE
		CITY:			ST. HELIER, CHANNEL ISLANDS
		STATE:			Y9
		ZIP:			JE4 9WG
		BUSINESS PHONE:		44 1534 753 623

	MAIL ADDRESS:	
		STREET 1:		44 ESPLANADE
		CITY:			ST. HELIER, CHANNEL ISLANDS
		STATE:			Y9
		ZIP:			JE4 9WG

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Index Venture Associates V Ltd
		CENTRAL INDEX KEY:			0001611751
		STATE OF INCORPORATION:			Y9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36517
		FILM NUMBER:		181096995

	BUSINESS ADDRESS:	
		STREET 1:		OGIER HOUSE
		STREET 2:		THE ESPLANADE
		CITY:			ST. HELIER
		STATE:			Y9
		ZIP:			JE4 9WC
		BUSINESS PHONE:		44 0 1534-504000

	MAIL ADDRESS:	
		STREET 1:		OGIER HOUSE
		STREET 2:		THE ESPLANADE
		CITY:			ST. HELIER
		STATE:			Y9
		ZIP:			JE4 9WC

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Yucca (Jersey) SLP
		CENTRAL INDEX KEY:			0001591294
		STATE OF INCORPORATION:			Y9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36517
		FILM NUMBER:		181096996

	BUSINESS ADDRESS:	
		STREET 1:		OGIER HOUSE
		STREET 2:		THE ESPLANADE
		CITY:			ST. HELIER
		STATE:			Y9
		ZIP:			JE4 9WG
		BUSINESS PHONE:		44-0-1534-833400

	MAIL ADDRESS:	
		STREET 1:		NO. 1 SEATON PLACE
		CITY:			ST. HELIER
		STATE:			Y9
		ZIP:			Y9 JE48YJ

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Minerva Neurosciences, Inc.
		CENTRAL INDEX KEY:			0001598646
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				260784194
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1601 TRAPELO ROAD
		STREET 2:		SUITE 286
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451
		BUSINESS PHONE:		617-600-7373

	MAIL ADDRESS:	
		STREET 1:		1601 TRAPELO ROAD
		STREET 2:		SUITE 286
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2018-09-27</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001598646</issuerCik>
        <issuerName>Minerva Neurosciences, Inc.</issuerName>
        <issuerTradingSymbol>NERV</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001503683</rptOwnerCik>
            <rptOwnerName>Index Venture Associates III Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EFG WEALTH SOLUTIONS (JERSEY) LTD.</rptOwnerStreet1>
            <rptOwnerStreet2>NO. 1 SEATON PLACE</rptOwnerStreet2>
            <rptOwnerCity>ST. HELIER</rptOwnerCity>
            <rptOwnerState>Y9</rptOwnerState>
            <rptOwnerZipCode>JEA 8YJ</rptOwnerZipCode>
            <rptOwnerStateDescription>JERSEY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001447962</rptOwnerCik>
            <rptOwnerName>Index Venture Associates IV Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EFG WEALTH SOLUTIONS (JERSEY) LTD.</rptOwnerStreet1>
            <rptOwnerStreet2>NO. 1 SEATON PLACE</rptOwnerStreet2>
            <rptOwnerCity>ST. HELIER</rptOwnerCity>
            <rptOwnerState>Y9</rptOwnerState>
            <rptOwnerZipCode>JEA 8YJ</rptOwnerZipCode>
            <rptOwnerStateDescription>JERSEY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001611751</rptOwnerCik>
            <rptOwnerName>Index Venture Associates V Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EFG WEALTH SOLUTIONS (JERSEY) LTD.</rptOwnerStreet1>
            <rptOwnerStreet2>NO. 1 SEATON PLACE</rptOwnerStreet2>
            <rptOwnerCity>ST. HELIER</rptOwnerCity>
            <rptOwnerState>Y9</rptOwnerState>
            <rptOwnerZipCode>JEA 8YJ</rptOwnerZipCode>
            <rptOwnerStateDescription>JERSEY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001591294</rptOwnerCik>
            <rptOwnerName>Yucca (Jersey) SLP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EFG WEALTH SOLUTIONS (JERSEY) LTD</rptOwnerStreet1>
            <rptOwnerStreet2>NO. 1 SEATON PLACE</rptOwnerStreet2>
            <rptOwnerCity>ST. HELIER</rptOwnerCity>
            <rptOwnerState>Y9</rptOwnerState>
            <rptOwnerZipCode>JEA 8YJ</rptOwnerZipCode>
            <rptOwnerStateDescription>JERSEY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2018-09-27</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>31684</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>12.5702</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4659222</value>
                    <footnoteId id="F3"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2018-09-28</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>34589</value>
                    <footnoteId id="F5"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>12.6151</value>
                    <footnoteId id="F6"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4624633</value>
                    <footnoteId id="F7"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Represents 5,492 shares sold by Index Ventures III (Jersey), L.P. (&quot;Index III Jersey&quot;), 11,156 shares sold by Index Ventures III (Delaware), L.P. (&quot;Index III Delaware&quot;), 199 shares sold by Index Ventures III Parallel Entrepreneur Fund (Jersey) L.P. (&quot;Index III Parallel&quot; and, together with Index III Jersey and Index III Delaware, the &quot;Index III Funds&quot;), 7,629 shares sold by Index Ventures IV (Jersey) L.P. (&quot;Index IV Jersey&quot;), 724 shares sold by Index Ventures IV Parallel Entrepreneur Fund (Jersey) L.P. (&quot;Index IV Parallel&quot; and, together with Index IV Jersey, the &quot;Index IV Funds&quot;), 6,033 shares sold by Index Ventures V (Jersey), L.P. (&quot;Index V Jersey&quot;), 49 shares sold by Index Ventures V Parallel Entrepreneur Fund (Jersey), L.P. (&quot;Index V Parallel&quot; and, together with Index V Jersey, the &quot;Index V Funds&quot;) and 402 shares sold by Yucca (Jersey) SLP (&quot;Yucca Jersey&quot;).</footnote>
        <footnote id="F2">The price reported in column 4 is a weighted average price.  These shares were sold in multiple transactions at prices ranging from $12.375 to $12.95.  The reporting persons undertake to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.</footnote>
        <footnote id="F3">Represents 807,603 shares held directly by Index III Jersey, 1,640,558 shares held directly by Index III Delaware, 29,225 shares held directly by Index III Parallel, 1,121,845 shares held directly by Index IV Jersey, 106,486 shares held directly by Index IV Parallel, 887,166 shares held directly by Index V Jersey, 7,189 shares sold by Index V Parallel and 59,150 shares held directly by Yucca Jersey.</footnote>
        <footnote id="F4">Index Venture Associates III Ltd. (&quot;Index III GP&quot;) is the general partner of the Index III Funds, Index Venture Associates IV Ltd. (&quot;Index IV GP&quot;) is the general partner of the Index IV Funds and Index Venture Associates V Ltd. (&quot;Index V GP&quot;) is the general partner of the Index V Funds.  Yucca (Jersey) SLP is the Administrator of the Index Co-Investment Scheme acting through Intertrust Employee Benefit Services Limited. Each of Index III GP, Index IV GP and Index V GP disclaims Section 16 beneficial ownership of the securities held by the Index III Funds, Index IV Funds and Index V Funds, respectively, and the shares held by Yucca Jersey, except to the extent of its respective pecuniary interest therein, if any, and this report shall not be deemed an admission that Index III GP, Index IV GP or Index V GP is the beneficial owner of such securities for Section 16 or any other purpose</footnote>
        <footnote id="F5">Represents 5,996 shares sold by Index III Jersey, 12,179 shares sold by Index III Delaware, 217 shares sold by Index III Parallel, 8,328 shares sold by Index IV Jersey, 791 shares sold by Index IV Parallel, 6,586 shares sold by Index V Jersey, 53 shares sold by Index V Parallel and 439 shares sold by Yucca Jersey.</footnote>
        <footnote id="F6">The price reported in column 4 is a weighted average price.  These shares were sold in multiple transactions at prices ranging from $12.45 to $12.75.  The reporting persons undertake to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.</footnote>
        <footnote id="F7">Represents 801,607 shares held directly by Index III Jersey, 1,628,379 shares held directly by Index III Delaware, 29,008 shares held directly by Index III Parallel, 1,113,517 shares held directly by Index IV Jersey, 105,695 shares held directly by Index IV Parallel, 880,580 shares held directly by Index V Jersey, 7,136 shares sold by Index V Parallel and 58,711 shares held directly by Yucca Jersey.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Index Venture Associates III Ltd., By: /s/ Nigel Greenwood, Director</signatureName>
        <signatureDate>2018-10-01</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Index Venture Associates IV Ltd., By: /s/ Michael Johnson, Alternate Director</signatureName>
        <signatureDate>2018-10-01</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Index Venture Associates V Ltd., By: /s/ Michael Johnson, Alternate Director</signatureName>
        <signatureDate>2018-10-01</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>YUCCA (JERSEY) SLP, By Intertrust Employee Benefit Services Limited, as authorized signatory of Yucca (Jersey) SLP in its capacity as Administrator of the Index Co-Investment Scheme, By: /s/ Sarah Earles, /s/ Michael Johnson, Its: Authorized Signatories</signatureName>
        <signatureDate>2018-10-01</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
