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v3.19.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 3 Months Ended
--- | ---
Mar. 31, 2019 | Mar. 31, 2018
Cash flows from operating activities: |  |
Net loss | $ (15,827,200) | $ (12,418,263)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 4,367 | 4,367
Amortization of debt discount recorded as interest expense |  | 24,252
Accretion of marketable securities premium | (242,708) | (54,212)
Amortization of right-of-use assets | 34,622 |
Stock-based compensation expense | 2,461,699 | 2,113,936
Changes in operating assets and liabilities |  |
Prepaid expenses and other current assets | 851,715 | (2,944,222)
Accounts payable | 1,225,897 | 1,389,295
Accrued expenses and other current liabilities | 1,911,423 | 952,720
Operating lease liabilities, current | 20,609 |
Other noncurrent liabilities |  | 395
Operating lease liabilities, noncurrent | (41,016) |
Net cash used in operating activities | (9,600,592) | (10,931,732)
Cash flows from investing activities: |  |
Proceeds from the maturity and redemption of marketable securities | 9,000,000 | 39,250,000
Purchase of marketable securities | (19,551,411) | (7,934,482)
Net cash (used in) provided by investing activities | (10,551,411) | 31,315,518
Cash flows from financing activities: |  |
Proceeds from exercise of stock options | 525,000 |
Repayments of notes payable |  | (1,289,882)
Net cash provided (used in) by financing activities | 525,000 | (1,289,882)
Net (decrease) increase in cash, cash equivalents and restricted cash | (19,627,003) | 19,093,904
Cash, cash equivalents and restricted cash |  |
Beginning of period | 50,334,871 | 26,131,821
End of period | 30,707,868 | 45,225,725
Supplemental disclosure of cash flow information |  |
Cash paid for interest |  | 53,975
Reconciliation of the Condensed Consolidated Statements of Cash Flows to the Condensed Consolidated Balance Sheets |  |
Cash and cash equivalents | 30,607,868 | 45,125,725
Restricted cash | 100,000 | 100,000
Total cash, cash equivalents and restricted cash | $ 30,707,868 | $ 45,225,725

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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
Name: | us-gaap_ShareBasedCompensation
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- References No definition available. + Details
Name: | us-gaap_SupplementalCashFlowInformationAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration