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CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Share data, unless otherwise specified | 12 Months Ended | 185 Months Ended
--- | --- | ---
Dec. 31, 2011 | Dec. 31, 2010 | Dec. 31, 2009 | Dec. 31, 2011
Revenues: |  |  |  |
Collaboration and research and development revenue |  | $ 100 |  | $ 3,100
Product Revenue | 699 | 574 | 910 | 3,021
Grant revenue |  | 12 | 1 | 3,648
Total revenues | 699 | 686 | 911 | 9,769
Operating expenses: |  |  |  |
Cost of goods sold | 360 | 418 | 545 | 1,752
Research and development | 9,206 | 6,414 | 9,766 | 185,799
Selling, general and administrative | 7,521 | 10,120 | 8,538 | 89,487
Goodwill and intangibles impairment |  |  |  | 7,934
Other restructuring costs |  |  | 366 | 2,634
Total operating expenses | 17,087 | 16,952 | 19,215 | 287,606
Operating loss | (16,388) | (16,266) | (18,304) | (277,837)
Other income (expense): |  |  |  |
Costs associated with aborted 2004 IPO |  |  |  | (3,550)
Payment under guarantee |  |  | (1,652) | (1,652)
Change in valuation of derivative | (20) |  |  | (328)
Change in valuation of warrants liability | 629 | (338) | (299) | 6,699
Warrant re-pricing |  |  | (44) | (44)
Foreign exchange losses | (74) | (68) | (144) | (4,329)
Interest income | 45 | 37 | 102 | 13,725
Interest expense |  | (43) | (177) | (4,677)
Total other (expense) income, net | 580 | (412) | (2,214) | 5,844
Loss before taxes | (15,808) | (16,678) | (20,518) | (271,993)
Income tax benefit | 565 | 657 | 948 | 18,444
Net loss | (15,243) | (16,021) | (19,570) | (253,549)
Dividend on preferred ordinary shares |  |  |  | (38,123)
Deemed dividend on convertible exchangeable preferred shares |  | (3,515) |  | (3,515)
Dividend on convertible exchangeable preferred shares | (728) | (167) | (1,228) | (3,657)
Net loss applicable to common shareholders | $ (15,971) | $ (19,703) | $ (20,798) | $ (298,844)
Net loss per share - basic and diluted (in dollars per share) | $ (0.32) | $ (0.52) | $ (0.94) |
Weighted average common shares outstanding (in shares) | 50,301,144 | 37,844,695 | 22,196,840 |

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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 141 -Paragraph 51 -Subparagraph g -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 2 -Paragraph 12, 13 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 86 -Paragraph 11, 12 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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- Definition The aggregate total costs related to selling a firm's product and services, as well as all other general and administrative expenses. Direct selling expenses (for example, credit, warranty, and advertising) are expenses that can be directly linked to the sale of specific products. Indirect selling expenses are expenses that cannot be directly linked to the sale of specific products, for example telephone expenses, Internet, and postal charges. General and administrative expenses include salaries of non-sales personnel, rent, utilities, communication, etc. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher AICPA -Name Accounting Research Bulletin (ARB) -Number 43 -Chapter 4 -Paragraph 5A -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Article 5 -Section 03 -Paragraph 4 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.4) -URI http://asc.fasb.org/extlink&oid=6880815&loc=d3e20235-122688 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 330 -SubTopic 10 -Section 30 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=6386349&loc=d3e3636-108311 + Details
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