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Stockholders' Equity (Details 3) (USD $) | 12 Months Ended | 197 Months Ended | 0 Months Ended | 12 Months Ended |  | 9 Months Ended | 12 Months Ended | 0 Months Ended | 12 Months Ended | 0 Months Ended | 12 Months Ended | 0 Months Ended |  | 0 Months Ended |  | 0 Months Ended |  | 0 Months Ended |  | 0 Months Ended |  | 0 Months Ended | 3 Months Ended | 0 Months Ended | 3 Months Ended | 12 Months Ended |  | 0 Months Ended | 12 Months Ended
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Dec. 31, 2012 | Dec. 31, 2012 | Dec. 14, 2012 Aspire Capital Fund, LLC | Dec. 31, 2012 Aspire Capital Fund, LLC | Dec. 14, 2012 Maximum Aspire Capital Fund, LLC | Dec. 31, 2003 Common stock | Dec. 31, 2012 Common stock | Dec. 31, 2011 Common stock | Dec. 31, 2010 Common stock | Dec. 31, 2009 Common stock | Dec. 31, 2007 Common stock | Dec. 31, 2004 Common stock | Mar. 31, 2002 Common stock | Mar. 31, 2000 Common stock | Mar. 31, 1998 Common stock | Feb. 16, 2007 Common stock warrants | Dec. 31, 2012 Common stock warrants | Dec. 31, 2011 Common stock warrants | Dec. 14, 2012 December 2012 stock issuance Aspire Capital Fund, LLC | Dec. 31, 2012 December 2012 stock issuance Common stock Aspire Capital Fund, LLC | Mar. 22, 2012 March 2012 Sale of Common Stock and Economic Rights | Jul. 07, 2011 July 2011 stock issuance | Dec. 31, 2012 July 2011 stock issuance | Jul. 07, 2011 July 2011 stock issuance Common stock | Jul. 07, 2011 July 2011 stock issuance Warrants | Oct. 07, 2010 October 2010 stock issuance | Dec. 31, 2012 October 2010 stock issuance | Oct. 07, 2010 October 2010 stock issuance Common stock | Oct. 07, 2010 October 2010 stock issuance Warrants | Oct. 07, 2010 October 2010 stock issuance Additional optional units | Jan. 25, 2010 January 2010 stock issuance, one | Dec. 31, 2012 January 2010 stock issuance, one | Jan. 25, 2010 January 2010 stock issuance, one Common stock | Jan. 25, 2010 January 2010 stock issuance, one Warrants | Jan. 13, 2010 January 2010 stock issuance, two | Dec. 31, 2012 January 2010 stock issuance, two | Jan. 13, 2010 January 2010 stock issuance, two Common stock | Jan. 13, 2010 January 2010 stock issuance, two Warrants | Jul. 29, 2009 July 2009 Series II stock issuance | Dec. 31, 2012 July 2009 Series II stock issuance | Jul. 29, 2009 July 2009 Series II stock issuance Common stock | Jul. 29, 2009 July 2009 Series II stock issuance Warrants | Jul. 29, 2009 July 2009 Series II stock issuance Series I Warrant | Mar. 31, 2010 July 2009 Series II stock issuance Series I Warrant | Jul. 29, 2009 July 2009 Series II stock issuance Series II Warrant | Mar. 31, 2010 July 2009 Series II stock issuance Series II Warrant | Dec. 31, 2012 July 2009 Series II stock issuance Series II Warrant | Dec. 31, 2011 July 2009 Series II stock issuance Series II Warrant | Dec. 31, 2012 December 2007 CEFF | Nov. 24, 2009 December 2007 CEFF Common stock Kingsbridge | Dec. 31, 2010 December 2007 CEFF Common stock Kingsbridge
Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares issued under purchase agreement |  |  | 158,982 |  |  |  | 233,530 |  |  |  |  |  |  |  |  |  |  |  | 158,982 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase price for shares issued under purchase agreement | $ 1,418,000 |  | $ 1,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares committed to purchase |  |  | 1,455,787 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,455,787 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Period of common stock purchase agreement |  |  | 2 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock purchase agreement, purchase commitment |  |  |  |  | 19,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  | 19,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock issued for non-cash consideration |  |  | 74,548 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 74,548 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-cash consideration associated with stock purchase agreement | 423,000 | 423,000 |  | 400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net proceeds |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,900,000 | 9,300,000 |  | 6,800,000 | 2,500,000 | 14,000,000 |  | 8,900,000 | 3,300,000 | 1,800,000 | 5,400,000 |  | 4,500,000 | 900,000 | 6,500,000 |  | 5,600,000 | 900,000 |  |  |  | 2,900,000 |  |  |  |  |  |  |  |  | 4,900,000
Shares sold (in shares) |  |  |  |  |  | 215,755 |  | 1,088,235 | 742,857 | 571,429 | 607,095 | 61,510 | 779 | 76,984 | 38,111 |  |  |  |  |  | 669,726 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 402,704
Offering price per unit (in dollars per unit) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 4.53 | $ 9.52 |  |  |  | $ 12.78 |  |  |  | $ 11.69 | $ 17.50 |  |  |  | $ 17.57 |  |  |  | $ 5.95 |  |  |  |  |  |  |  |  |  |  |  |
Number of days used to calculate average closing price |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount to be paid as percentage of future litigation settlement amount received |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lock-up period from the date of issuance |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 year |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Units issued (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,088,235 |  |  |  | 1,189,027 |  |  |  |  | 335,714 |  |  |  | 407,143 |  |  |  | 571,429 |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10,400,000 |  |  |  | 15,200,000 |  |  |  | 6,900,000 | 5,900,000 |  |  |  | 7,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares of common stock for each capital unit |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  | 1 |  |  |  |  | 1 |  |  |  | 1 |  |  |  | 1 |  |  |  |  |  |  |  |  |  |
Term of warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years |  |  |  | 5 years |  |  |  |  | 5 years |  |  |  | 5 years |  |  |  |  | 7 months |  | 5 years |  |  |  |  |  |
Number of common stock purchase warrants for each capital unit |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.5 |  |  |  |  | 1 |  |  |  | 1 |  |  |  |  | 1 |  | 1 |  |  |  |  |  |
Exercise price of warrants (in dollars per share) | $ 22.96 | $ 22.96 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 9.52 |  | $ 9.52 |  | $ 13.44 |  | $ 13.44 |  |  | $ 22.82 |  | $ 19.95 |  | $ 19.95 |  | $ 22.82 |  | $ 7.00 |  |  | $ 7.00 |  | $ 7.00 |  |  |  | $ 9.80 |  |
Period from which warrants or rights are exercisable |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6 months |  |  |  |  | 9 months |  |  |  | 6 months |  |  |  | 6 months |  |  |  |  | 6 months |  | 6 months |  |  |  |  |  |
Warrants outstanding | 1,973,427 | 1,973,427 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 544,117 |  |  |  | 594,513 |  |  |  |  | 101,785 |  |  |  | 100,714 |  |  |  | 98,893 |  |  |  |  |  |  | 98,893 |  | 14,285 |  |
Transaction date fair value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6,800,000 |  | 100,000 |  |  |  |  |  |  | 3,500,000 |  |  |  | 5,100,000 | 2,800,000 |  |  |  | 1,000,000 |  |  |  | 1,300,000 |  |  |  |  |  |  | 600,000 |  |  |  |  |  |
Risk free interest rate (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4.58% |  |  |  |  |  |  |  |  | 1.74% |  |  |  |  |  |  |  |  | 2.39% |  |  |  | 2.55% |  |  |  |  |  |  | 2.69% |  |  |  |  |  |
Expected volatility (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 85.00% |  |  |  |  |  |  |  |  | 99.00% |  |  |  |  |  |  |  |  | 90.00% |  |  |  | 90.00% |  |  |  |  |  |  | 90.00% |  |  |  |  |  |
Expected dividend yield (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.00% |  |  |  |  |  |  |  |  | 0.00% |  |  |  |  |  |  |  |  | 0.00% |  |  |  | 0.00% |  |  |  |  |  |  | 0.00% |  |  |  |  |  |
Contractual life |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6 years 10 months 17 days |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |  |  |  |  | 5 years |  |  |  | 5 years |  |  |  |  |  |  | 5 years |  |  |  |  |  |
Underwriting discounts and commissions and other fees and expenses |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net proceeds per share (in dollars per share/warrant/unit) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 6.23 | $ 4.62 |  |  | $ 7.49 | $ 5.53 | $ 3.01 |  |  | $ 13.51 | $ 9.03 |  |  | $ 13.65 | $ 9.24 |  |  |  |  |  |  |  |  |  |  |  |  |
Number of common shares that can be acquired upon exercise of each warrant |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.5 |  |  |  | 1 |  |  |  |  | 0.30 |  |  |  | 0.25 |  |  |  |  | 0.625 |  | 0.1838805 |  |  |  |  |  |
Number of additional units that can be acquired upon exercise of right |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 151,773 |  |  |  |  |  |  |  |  |  |  |  |  |  | 594,513 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from exercise of warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,500,000 |  | 43,266 |  |  |  |  |
Stock issued upon exercise of warrants (in shares) |  |  |  |  |  |  |  |  | 374,038 |  |  | 3,233 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6,181 | 0 | 0 |  |  |
Number of common shares committed to be purchased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 583,513 |
Value of common shares committed to be purchased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 60,000,000 |
Period over which common shares are committed to be purchased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3 years |
Change in value of warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 600,000 | 600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gains on change in value of warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 51,000 | $ 51,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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