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Taxes (Details 2) (USD $) | 12 Months Ended | 197 Months Ended
--- | --- | ---
Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010 | Dec. 31, 2012
Reconciliation of the (benefit) provision for income taxes |  |  |  |
Loss before income taxes | $ (15,107,000) | $ (15,168,000) | $ (15,547,000) |
Income tax expense computed at statutory federal tax rate | (5,136,000) | (5,157,000) | (5,286,000) |
Disallowed expenses and non-taxable income | 176,000 | (141,000) | (490,000) |
Loss surrendered to generate R&D credit | 3,025,000 | 1,372,000 | 1,605,000 |
Additional research and development tax relief | (2,656,000) | (2,260,000) | (793,000) |
Change in valuation allowance | (579,000) | 2,952,000 | 3,605,000 |
Research and development tax credit rate difference |  |  | 132,000 |
Foreign items, including change in tax rates | 3,819,000 | 2,669,000 | 570,000 |
Current - total | (1,351,000) | (565,000) | (657,000) | (19,795,000)
Significant components of the entity's deferred tax assets |  |  |  |
Net operating loss carryforwards | 42,399,000 | 43,870,000 |  | 42,399,000
Depreciation, amortization and impairment of property and equipment | 1,654,000 | 1,772,000 |  | 1,654,000
Stock Options | 1,451,000 | 1,372,000 |  | 1,451,000
Accrued Expenses | 3,389,000 | 3,435,000 |  | 3,389,000
Other | 45,000 | 96,000 |  | 45,000
Translation adjustment | 1,277,000 | 249,000 |  | 1,277,000
Deferred Tax Assets | 50,215,000 | 50,794,000 |  | 50,215,000
Valuation allowance for deferred tax assets | (50,215,000) | (50,794,000) |  | (50,215,000)
Taxes |  |  |  |
Material uncertain tax positions | 0 | 0 |  | 0
Federal |  |  |  |
Taxes |  |  |  |
NOLs carryforward | 19,200,000 | 18,600,000 |  | 19,200,000
Foreign |  |  |  |
Taxes |  |  |  |
NOLs carryforward | 153,400,000 | 148,200,000 |  | 153,400,000
State |  |  |  |
Taxes |  |  |  |
NOLs carryforward | $ 18,300,000 |  |  | $ 18,300,000

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