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CONSOLIDATED STATEMENTS OF OPERATIONS (USD $)
In Thousands, except Share data, unless otherwise specified
 12 Months Ended 197 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2012
Revenues:        
Collaboration and research and development revenue     $ 100 $ 3,100
Grant revenue 69   12 3,717
Total revenues 69   112 6,817
Operating expenses:        
Research and development 6,592 9,206 6,414 192,391
General and administrative 8,580 6,542 8,833 89,411
Goodwill and intangibles impairment       2,747
Other restructuring costs       2,634
Total operating expenses 15,172 15,748 15,247 287,183
Operating loss (15,103) (15,748) (15,135) (280,366)
Other income (expense):        
Costs associated with aborted 2004 IPO       (3,550)
Payment under guarantee       (1,652)
Non-cash consideration associated with stock purchase agreement (423)     (423)
Change in valuation of Economic Rights (23)     (23)
Change in valuation of liabilities measured at fair value 51 609 (338) 6,378
Foreign exchange losses 292 (74) (68) (4,005)
Interest income 22 45 37 13,747
Interest expense     (43) (4,567)
Other income (expense) 77     77
Total other (expense) income, net (4) 580 (412) 5,982
(Loss) income from continuing operations before taxes (15,107) (15,168) (15,547) (274,384)
Income tax benefit 1,351 565 657 19,795
Net loss from continuing operations (13,756) (14,603) (14,890) (254,589)
Discontinued operations:        
(Loss) income from discontinued operations, net of tax of $0, $0 and $(337) for the years ended December 31, 2010, 2011 and 2012, respectively 570 (640) (1,131) (12,146)
Net loss (13,186) (15,243) (16,021) (266,735)
Dividend on preferred ordinary shares       (38,123)
Deemed dividend on convertible exchangeable preferred shares     (3,515) (3,515)
Dividend on convertible exchangeable preferred shares (728) (728) (167) (4,385)
Net loss applicable to common shareholders $ (13,914) $ (15,971) $ (19,703) $ (312,758)
Net loss per share, continuing operations - basic and diluted (in dollars per share) $ (1.75) $ (2.13) $ (3.43)  
Net loss per share, discontinued operations - basic and diluted (in dollars per share) $ 0.07 $ (0.09) $ (0.21)  
Net loss per share - basic and diluted (in dollars per share) $ (1.68) $ (2.22) $ (3.64)  
Weighted average common shares outstanding (in shares) 8,291,802 7,185,877 5,406,385