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Stock-Based Compensation Arrangements (Details 3) (USD $)
 12 Months Ended 197 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2012
May 23, 2012
Stock-based compensation          
Number of shares reserved for issuance         10,000,000
Number of shares reserved for issuance before amendment         5,200,000
Vesting period 4 years        
Compensation cost $ 380,000 $ 882,000 $ 1,746,000    
Cash proceeds 94,000 3,000   267,000  
Number of options outstanding          
Exercised (in shares) (33,351) (948)      
Stock options
          
Stock-based compensation          
Expiration period 10 years        
Vesting period 4 years        
Weighted average grant-date fair value (in dollars per share) $ 2.52 $ 8.05 $ 9.80    
Total remaining unrecognized compensation cost 400,000     400,000  
Weighted-average remaining requisite service period of recognition of unrecognized compensation cost 2 years 3 months 7 days        
Cash proceeds 100,000 3,000 100,000    
Total intrinsic value of options exercised 100,000 7,000 200,000    
Income tax benefits recorded for share based payments 0 0 0    
Number of options outstanding          
Options outstanding at the beginning of the period (in shares) 502,249 498,562      
Granted (in shares) 33,571 28,500      
Exercised (in shares) (33,351) (948) (24,901)    
Cancelled / forfeited (in shares) (39,446) (23,865)      
Options outstanding at the end of the period (in shares) 463,023 502,249 498,562 463,023  
Unvested at the end of the period (in shares) 69,781     69,781  
Vested and exercisable at the end of the period (in shares) 393,242     393,242  
Weighted average exercise price          
Options outstanding at the beginning of the period (in dollars per share) $ 26.11 $ 27.72      
Granted (in dollars per share) $ 3.29 $ 10.64      
Exercised (in dollars per share) $ 3.09 $ 2.87      
Cancelled / forfeited (in dollars per share) $ 20.21 $ 40.53      
Options outstanding at the end of the period (in dollars per share) $ 26.61 $ 26.11 $ 27.72 $ 26.61  
Unvested at the end of the period (in dollars per share) $ 8.83     $ 8.83  
Vested and exercisable at the end of the period (in dollars per share) $ 29.77     $ 29.77  
Weighted average remaining contractual term          
Options outstanding 5 years 6 months 29 days 6 years 5 months 8 days 7 years 2 months 19 days    
Unvested at the end of the period 8 years 5 months 8 days        
Vested and exercisable at the end of the period 5 years 25 days        
Aggregate intrinsic value          
Options outstanding 347 140 938 347  
Unvested at the end of the period 68     68  
Vested and exercisable at the end of the period 279     279  
Stock options | Employees and directors
          
Stock-based compensation          
Grant date fair value 100,000 200,000 600,000    
Compensation cost $ 12,000 $ 24,000 $ 50,000    
Weighted average grant-date fair value (in dollars per share) $ 2.52 $ 8.05 $ 9.80    
Number of options outstanding          
Granted (in shares) 33,571 28,500 100,000