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CONSOLIDATED STATEMENTS OF OPERATIONS (USD $)
In Thousands, except Share data, unless otherwise specified
 3 Months Ended 8 Months Ended 9 Months Ended 12 Months Ended 185 Months Ended 194 Months Ended
Sep. 30, 2012
Sep. 30, 2011
Mar. 31, 1997
Sep. 30, 2012
Sep. 30, 2011
Dec. 31, 2003
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Dec. 31, 2008
Dec. 31, 2007
Dec. 31, 2006
Dec. 31, 2005
Dec. 31, 2004
Mar. 31, 2003
Mar. 31, 2002
Mar. 31, 2001
Mar. 31, 2000
Mar. 31, 1999
Mar. 31, 1998
Dec. 31, 2011
Sep. 30, 2012
Revenues:                                            
Collaboration and research and development revenue               $ 100                         $ 3,100 $ 3,100
Grant revenue 38     64       12 1                       3,648 3,712
Total revenues 38     64     0 112 1                       6,748 6,812
Operating expenses:                                            
Research and development 1,532 2,066   4,596 7,005   9,206 6,414 9,766                       185,799 190,395
General and administrative 2,028 1,814   5,917 5,136   6,542 8,833 6,631                       80,831 86,748
Goodwill and intangibles impairment                                         2,747 2,747
Other restructuring costs                 366                       2,634 2,634
Total operating expenses 3,560 3,880   10,513 12,141   15,748 15,247 16,763                       272,011 282,524
Operating loss (3,522) (3,880)   (10,449) (12,141)   (15,748) (15,135) (16,762)                       (265,263) (275,712)
Other income (expense):                                            
Costs associated with aborted 2004 IPO                                         (3,550) (3,550)
Payment under guarantee                 (1,652)                       (1,652) (1,652)
Change in valuation of liabilities measured at fair value 1 440   51 643   609 (338) (343)                       6,327 6,378
Foreign exchange losses 6 28   237 (59)   (74) (68) (144)                       (4,397) (4,060)
Interest income 5 9   17 33   45 37 102                       13,725 13,742
Interest expense               (43) (170)                       (4,567) (4,567)
Total other (expense) income, net (50) 477   409 617   580 (412) (2,207)                       5,986 6,395
Loss from continuing operations before taxes (3,572) (3,403)   (10,040) (11,524)   (15,168) (15,547) (18,969)                       (259,277) (269,317)
Income tax benefit 419 126   714 443   565 657 948                       18,444 19,158
Net loss from continuing operations (3,153) (3,277)   (9,326) (11,081)   (14,603) (14,890) (18,021)                       (240,833) (250,159)
Discontinued operations:                                            
Loss from discontinued operations, net of tax of $0 for all periods presented 1,263 (168)   904 (504)   (640) (1,131) (1,549)                       (12,716) (11,812)
Net loss (1,890) (3,445) (290) (8,422) (11,585) (14,977) (15,243) (16,021) (19,570) (40,386) (24,053) (29,258) (18,048) (22,742) (15,542) (14,853) (10,382) (5,686) (3,964) (2,534) (253,549) (261,971)
Dividend on preferred ordinary shares                                         (38,123) (38,123)
Deemed dividend on convertible exchangeable preferred shares               (3,515)                         (3,515) (3,515)
Dividend on convertible exchangeable preferred shares (182) (182)   (546) (546)   (728) (167) (1,228)                       (3,657) (4,203)
Net loss applicable to common shareholders $ (2,072) $ (3,627)   $ (8,968) $ (12,131)   $ (15,971) $ (19,703) $ (20,798)                       $ (298,844) $ (307,812)
Net loss per share, continuing operations                                            
basic and diluted (in dollars per share) $ (0.40) $ (0.45)   $ (1.20) $ (1.66)   $ (2.13) $ (3.43) $ (6.07)                          
Net loss per share, discontinued operations                                            
basic and diluted (in dollars per share) $ 0.15 $ (0.02)   $ 0.11 $ (0.07)   $ (0.09) $ (0.21) $ (0.49)                          
Net loss per share - basic and diluted (in dollars per share) $ (0.25) $ (0.47)   $ (1.09) $ (1.73)   $ (2.22) $ (3.64) $ (6.56)                          
Weighted average common shares outstanding (in shares) 8,429,269 7,673,096   8,227,721 6,997,391   7,185,877 5,406,385 3,170,977