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Property, Plant and Equipment (Tables)
 12 Months Ended
Dec. 31, 2013
Property, Plant and Equipment  
Schedule of property, plant and equipment
    Useful lives in years from   December 31,  
    date of acquisition   2012     2013  
                 
Leasehold improvements   5 to 15 years   $ 867     $ 922  
Research and laboratory equipment   3 to 5 years     5,519       5,668  
Office equipment and furniture   3 to 5 years     1,325       1,338  
          7,711       7,928  
Less: accumulated depreciation and amortization         (7,582 )     (7,653 )
        $ 129     $ 275