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CONSOLIDATED STATEMENTS OF OPERATIONS (USD $)
In Thousands, except Share data, unless otherwise specified
 12 Months Ended 209 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2013
Revenues:        
Collaboration and research and development revenue       $ 3,100
Grant revenue 1,084 69   4,801
Total revenues 1,084 69   7,901
Operating expenses:        
Research and development 11,277 6,592 9,206 203,668
General and administrative 7,781 8,580 6,542 97,192
Goodwill and intangibles impairment       2,747
Other restructuring costs       2,634
Total operating expenses 19,058 15,172 15,748 306,241
Operating loss (17,974) (15,103) (15,748) (298,340)
Other income (expense):        
Costs associated with aborted 2004 IPO       (3,550)
Payment under guarantee       (1,652)
Non-cash consideration associated with stock purchase agreement (98) (423)   (521)
Change in valuation of Economic Rights 570 (23)   547
Change in valuation of liabilities measured at fair value   51 609 6,378
Foreign exchange (losses) gains 62 292 (74) (3,943)
Interest income 13 22 45 13,760
Interest expense       (4,567)
Other income (expense), net 5,547 77   5,624
Total other income (expense), net 6,094 (4) 580 12,076
Loss from continuing operations before taxes (11,880) (15,107) (15,168) (286,264)
Income tax benefit 1,670 1,351 565 21,465
Net loss from continuing operations (10,210) (13,756) (14,603) (264,799)
Discontinued operations:        
(Loss) income from discontinued operations 91 907 (640) (11,718)
Income tax on discontinued operations (34) (337)   (371)
Net (loss) income from discontinued operations 57 570 (640) (12,089)
Net loss (10,153) (13,186) (15,243) (276,888)
Dividend on preferred ordinary shares       (38,123)
Deemed dividend on convertible exchangeable preferred shares (9,027)     (12,542)
Dividend on convertible exchangeable preferred shares (298) (728) (728) (4,683)
Net loss applicable to common shareholders $ (19,478) $ (13,914) $ (15,971) $ (332,236)
Net loss per share, continuing operations - basic and diluted (in dollars per share) $ (1.29) $ (1.75) $ (2.13)  
Net (loss) income per share, discontinued operations - basic and diluted (in dollars per share) $ 0.00 $ 0.07 $ (0.09)  
Net loss per share - basic and diluted (in dollars per share) $ (1.28) $ (1.68) $ (2.22)  
Weighted average common shares outstanding (in shares) 15,158,225 8,291,802 7,185,877