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Stockholders' Equity (Details 4) (USD $)
 1 Months Ended 8 Months Ended 9 Months Ended 12 Months Ended 209 Months Ended 9 Months Ended 12 Months Ended 0 Months Ended 12 Months Ended 0 Months Ended 0 Months Ended 12 Months Ended 0 Months Ended 1 Months Ended 0 Months Ended 1 Months Ended 0 Months Ended 0 Months Ended 0 Months Ended 1 Months Ended 1 Months Ended 0 Months Ended 0 Months Ended 1 Months Ended 1 Months Ended 3 Months Ended 1 Months Ended 3 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended
Apr. 30, 2013
Mar. 31, 1997
Dec. 31, 2003
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Dec. 31, 2007
Dec. 31, 2004
Mar. 31, 2003
Mar. 31, 2002
Mar. 31, 2000
Mar. 31, 1998
Dec. 31, 2013
Dec. 31, 2003
Common stock
Dec. 31, 2013
Common stock
Dec. 31, 2012
Common stock
Dec. 31, 2011
Common stock
Dec. 31, 2010
Common stock
Dec. 31, 2009
Common stock
Dec. 31, 2007
Common stock
Dec. 31, 2004
Common stock
Mar. 31, 2002
Common stock
Mar. 31, 2000
Common stock
Mar. 31, 1998
Common stock
Feb. 16, 2007
Common stock warrants
Dec. 31, 2012
Common stock warrants
Dec. 31, 2011
Common stock warrants
Dec. 14, 2012
November 2013 stock issuance
Common stock
Aspire Capital Fund, LLC
Dec. 14, 2012
November 2013 stock issuance
Common stock
Maximum
Aspire Capital Fund, LLC
Dec. 14, 2012
December 2012 stock issuance
Common stock
Aspire Capital Fund, LLC
Dec. 31, 2012
December 2012 stock issuance
Common stock
Aspire Capital Fund, LLC
Dec. 14, 2012
December 2012 stock issuance
Common stock
Maximum
Aspire Capital Fund, LLC
May 16, 2013
May 2013 sale of common stock
May 21, 2013
May 2013 sale of common stock
Mar. 22, 2012
March 2012 Sale of Common Stock and Economic Rights
Mar. 22, 2012
March 2012 Sale of Common Stock and Economic Rights
Jul. 07, 2011
July 2011 stock issuance
Dec. 31, 2013
July 2011 stock issuance
Jul. 07, 2011
July 2011 stock issuance
Common stock
Jul. 07, 2011
July 2011 stock issuance
Warrants
Oct. 07, 2010
October 2010 stock issuance
Dec. 31, 2013
October 2010 stock issuance
Oct. 07, 2010
October 2010 stock issuance
Common stock
Oct. 07, 2010
October 2010 stock issuance
Warrants
Oct. 07, 2010
October 2010 stock issuance
Additional optional units
Jan. 25, 2010
January 2010 stock issuance, one
Dec. 31, 2013
January 2010 stock issuance, one
Jan. 25, 2010
January 2010 stock issuance, one
Common stock
Jan. 25, 2010
January 2010 stock issuance, one
Warrants
Jan. 13, 2010
January 2010 stock issuance, two
Dec. 31, 2013
January 2010 stock issuance, two
Jan. 13, 2010
January 2010 stock issuance, two
Common stock
Jan. 13, 2010
January 2010 stock issuance, two
Warrants
Jul. 29, 2009
July 2009 Series II stock issuance
Dec. 31, 2013
July 2009 Series II stock issuance
Jul. 29, 2009
July 2009 Series II stock issuance
Common stock
Jul. 29, 2009
July 2009 Series II stock issuance
Warrants
Jul. 29, 2009
July 2009 Series II stock issuance
Series I Warrant
Mar. 31, 2010
July 2009 Series II stock issuance
Series I Warrant
Jul. 29, 2009
July 2009 Series II stock issuance
Series II Warrant
Mar. 31, 2010
July 2009 Series II stock issuance
Series II Warrant
Dec. 31, 2013
July 2009 Series II stock issuance
Series II Warrant
Dec. 31, 2012
July 2009 Series II stock issuance
Series II Warrant
Dec. 31, 2011
July 2009 Series II stock issuance
Series II Warrant
Nov. 24, 2009
December 2007 CEFF
Common stock
Kingsbridge
Dec. 31, 2010
December 2007 CEFF
Common stock
Kingsbridge
Common Stock                                                                                                                                        
Number of shares issued under purchase agreement                                 2,133,401 233,530                       511,509   158,982                                                                        
Purchase price for shares issued under purchase agreement       $ 9,126,000 $ 1,418,000                       $ 2,000                         $ 2,000,000   $ 1,000,000                                                                        
Shares committed to purchase                                                             3,042,038     1,455,787                                                                    
Period of common stock purchase agreement                                                           2 years   2 years                                                                        
Common stock purchase agreement, purchase commitment                                                             18,000,000     19,000,000                                                                    
Stock issued for non-cash consideration                                                           166,105   74,548                                                                        
Shares committed for sale under agreement                                                                     6,666,667                                                                  
Common stock, par value (in dollars per share)       $ 0.001 $ 0.001                   $ 0.001                                       $ 0.001                                                                  
Offering price per unit (in dollars per unit)                                                                     $ 3.00 $ 3.00   $ 4.53 $ 9.52     $ 9.52 $ 12.78       $ 11.69 $ 17.50       $ 17.57       $ 5.95                        
Shares sold (in shares)                               215,755 6,833,334   1,088,235 742,857 571,429 607,095 61,510 779 76,984 38,111                   6,833,334   669,726                                                           402,704
Number of share sold that were subject to the underwriters' over-allotment option                                                                       166,667                                                                
Proceeds from sale of common stock, net of certain fees and expenses   1,000 27,635,000 19,006,000   9,272,000 11,897,000 2,847,000 33,357,000 8,541,000     12,717,000 4,217,000     6,000   1,000 1,000 1,000 1,000                           19,000,000                                                                
Non-cash consideration associated with stock purchase agreement       98,000 423,000                   521,000                                   400,000                                                                      
Net proceeds                                                                           2,900,000 9,300,000   6,800,000 2,500,000 14,000,000   8,900,000 3,300,000 1,800,000 5,400,000   4,500,000 900,000 6,500,000   5,600,000 900,000       2,900,000                 4,900,000
Number of days used to calculate average closing price                                                                           10 days                                                            
Amount to be paid as percentage of future litigation settlement amount received                                                                         10.00% 10.00%                                                            
Lock-up period from the date of issuance                                                                           1 year                                                            
Units issued (in shares)                                                                             1,088,235       1,189,027         335,714       407,143       571,429                        
Gross proceeds                                                                             10,400,000       15,200,000       6,900,000 5,900,000       7,200,000                                
Number of shares of common stock for each capital unit                                                                                 1       1         1       1       1                    
Term of warrants                                                                                   5 years       5 years         5 years       5 years         7 months   5 years            
Number of common stock purchase warrants for each capital unit                                                                                   0.5       1         1       1         1   1            
Exercise price of warrants (in dollars per share)       17.06                     17.06                                                 9.52       13.44   13.44     22.82   19.95   19.95   22.82   7.00     7   7            
Period from which warrants or rights are exercisable                                                                                   6 months         9 months       6 months       6 months         6 months   6 months            
Warrants outstanding       1,591,795                     1,591,795                                                 544,117       594,513         101,785       100,714       98,893             98,893        
Transaction date fair value                                                     6,800,000                             3,500,000       5,100,000 2,800,000       1,000,000       1,300,000             600,000            
Risk free interest rate (as a percent)                                                     4.58%                             1.74%                 2.39%       2.55%             2.69%            
Expected volatility (as a percent)                                                     85.00%                             99.00%                 90.00%       90.00%             90.00%            
Expected dividend yield (as a percent)                                                     0.00%                             0.00%                 0.00%       0.00%             0.00%            
Contractual life                                                     6 years 10 months 17 days                             5 years                 5 years       5 years             5 years            
Underwriting discounts and commissions and other fees and expenses                                                                             1,100,000                                                          
Net proceeds per share (in dollars per share/warrant/unit)                                                                                 $ 6.23 $ 4.62     $ 7.49 $ 5.53 $ 3.01     $ 13.51 $ 9.03     $ 13.65 $ 9.24                          
Number of common shares that can be acquired upon exercise of each warrant                                                                                           0.5         0.30       0.25         0.625   0.1838805            
Number of additional units that can be acquired upon exercise of right                                                     151,773                                       594,513                                          
Proceeds from exercise of warrants                                                                                                                         2,500,000   43,266          
Stock issued upon exercise of warrants (in shares)                                       374,038     3,233                                                                               6,181 0 0 0    
Number of common shares committed to be purchased                                                                                                                                     583,513  
Value of common shares committed to be purchased                                                                                                                                     60,000,000  
Period over which common shares are committed to be purchased                                                                                                                                     3 years  
Change in value of warrants                                                       600,000 600,000                                                                              
Gains on change in value of warrants                                                       100,000 100,000                                                                              
Economic Rights settled for payments 600,000                                                                                                                                      
Exercise of Stock Options                                                                                                                                        
Stock option exercised (in shares)         33,351 948                   936           3,644     324                                                                                      
Proceeds from exercise of stock options     $ 115,000   $ 100,000 $ 3,000     $ 163,000   $ 12,000 $ 106,000 $ 40,000