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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) (USD $) In Thousands, except Share data, unless otherwise specified | 3 Months Ended | 212 Months Ended
--- | --- | ---
Mar. 31, 2014 | Mar. 31, 2013 | Mar. 31, 2014
Revenues: |  |  |
Collaboration and research and development revenue |  |  | $ 3,100
Grant revenue | 396 | 212 | 5,197
Total revenues | 396 | 212 | 8,297
Operating expenses: |  |  |
Research and development | 4,344 | 1,580 | 208,012
General and administrative | 1,462 | 2,683 | 98,654
Goodwill and intangibles impairment |  |  | 2,747
Other restructuring costs |  |  | 2,634
Total operating expenses | 5,806 | 4,263 | 312,047
Operating loss | (5,410) | (4,051) | (303,750)
Other income (expense): |  |  |
Costs associated with aborted 2004 IPO |  |  | (3,550)
Payment under guarantee |  |  | (1,652)
Change in valuation of financial instruments associated with stock purchase agreement | (47) |  | (568)
Change in valuation of Economic Rights |  | 570 | 547
Change in valuation of liabilities measured at fair value |  |  | 6,378
Foreign exchange gains (losses) | 10 | 120 | (3,933)
Interest income | 1 | 1 | 13,761
Interest expense |  |  | (4,567)
Other income, net |  | 4 | 5,624
Total other income (expense) | (36) | 695 | 12,040
Loss from continuing operations before taxes | (5,446) | (3,356) | (291,710)
Income tax benefit | 569 | 258 | 22,034
Net loss from continuing operations | (4,877) | (3,098) | (269,676)
Discontinued operations: |  |  |
Income (loss) from discontinued operations | 13 | 26 | (11,705)
Income tax on discontinued operations | (5) | (10) | (376)
Net income (loss) from discontinued operations | 8 | 16 | (12,081)
Net loss | (4,869) | (3,082) | (281,757)
Dividend on preferred ordinary shares |  |  | (38,123)
Deemed dividend on convertible exchangeable preferred shares |  | (8,366) | (12,542)
Dividend on convertible exchangeable preferred shares | (50) | (122) | (4,733)
Net loss applicable to common shareholders | $ (4,919) | $ (11,570) | $ (337,155)
Net loss per share, continuing operations - Basic and diluted (in dollars per share) | $ (0.25) | $ (1.18) |
Net loss per share, discontinued operations - Basic and diluted (in dollars per share) | $ 0.00 | $ 0.00 |
Net loss applicable to common shareholders - Basic and diluted (in dollars per share) | $ (0.25) | $ (1.18) |
Weighted average shares of common stock outstanding (in shares) | 19,530,322 | 9,790,474 |

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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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- Definition Total revenue from sale of goods and services rendered during the reporting period, in the normal course of business, reduced by sales returns and allowances, and sales discounts. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.1) -URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 1 -Article 5 + Details
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- Definition The aggregate total costs related to selling a firm's product and services, as well as all other general and administrative expenses. Direct selling expenses (for example, credit, warranty, and advertising) are expenses that can be directly linked to the sale of specific products. Indirect selling expenses are expenses that cannot be directly linked to the sale of specific products, for example telephone expenses, Internet, and postal charges. General and administrative expenses include salaries of non-sales personnel, rent, utilities, communication, etc. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.4) -URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 4 -Article 5 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 330 -SubTopic 10 -Section 30 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=6386349&loc=d3e3636-108311 + Details
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- Definition Number of [basic] shares or units, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time within a reporting period that common shares or units have been outstanding to the total time in that period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 45 -Paragraph 10 -URI http://asc.fasb.org/extlink&oid=7655603&loc=d3e1448-109256 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Weighted-Average Number of Common Shares Outstanding -URI http://asc.fasb.org/extlink&oid=6528421 + Details
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