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CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS (Unaudited) (USD $) In Thousands, unless otherwise specified | 9 Months Ended
--- | ---
Sep. 30, 2014 | Sep. 30, 2013
Operating activities: |  |
Net loss | $ (14,588) | $ (6,594)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Change in valuation of liabilities measured at fair value | (20) | (1,120)
Change in valuation of financial instruments associated with stock purchase agreement | 115 |
Depreciation | 115 | 58
Gain on sale of patents |  | (5,500)
Stock-based compensation | 589 | 244
Changes in operating assets and liabilities: |  |
Prepaid expenses and other assets | (842) | (746)
Accounts payable and other current liabilities | (403) | 837
Net cash used in operating activities | (15,034) | (12,821)
Investing activities: |  |
Purchase of property, plant and equipment | (302) | (99)
Minimum royalty payments received from termination of ALIGN license agreement | 288 | 264
Proceeds from sale of patents |  | 5,500
Net cash provided by (used in) investing activities | (14) | 5,665
Financing activities: |  |
Proceeds from issuance of common stock, net of issuance costs | 10,965 | 25,636
Payment of preferred stock dividend | (150) | (255)
Net cash provided by financing activities | 10,815 | 25,381
Effect of exchange rate changes on cash and cash equivalents | (206) | (150)
Net increase (decrease) in cash and cash equivalents | (4,439) | 18,075
Cash and cash equivalents, beginning of period | 31,146 | 16,412
Cash and cash equivalents, end of period | 26,707 | 34,487
Cash received during the period for: |  |
Interest | 5 | 9
Taxes | 1,811 | 970
Schedule of non-cash transactions: |  |
Issuance of Ordinary shares in lieu of cash bonus |  | $ 181

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