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CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS (Unaudited) (USD $)
In Thousands, unless otherwise specified
 9 Months Ended
Sep. 30, 2014
Sep. 30, 2013
Operating activities:    
Net loss $ (14,588) $ (6,594)
Adjustments to reconcile net loss to net cash used in operating activities:    
Change in valuation of liabilities measured at fair value (20) (1,120)
Change in valuation of financial instruments associated with stock purchase agreement 115  
Depreciation 115 58
Gain on sale of patents   (5,500)
Stock-based compensation 589 244
Changes in operating assets and liabilities:    
Prepaid expenses and other assets (842) (746)
Accounts payable and other current liabilities (403) 837
Net cash used in operating activities (15,034) (12,821)
Investing activities:    
Purchase of property, plant and equipment (302) (99)
Minimum royalty payments received from termination of ALIGN license agreement 288 264
Proceeds from sale of patents   5,500
Net cash provided by (used in) investing activities (14) 5,665
Financing activities:    
Proceeds from issuance of common stock, net of issuance costs 10,965 25,636
Payment of preferred stock dividend (150) (255)
Net cash provided by financing activities 10,815 25,381
Effect of exchange rate changes on cash and cash equivalents (206) (150)
Net increase (decrease) in cash and cash equivalents (4,439) 18,075
Cash and cash equivalents, beginning of period 31,146 16,412
Cash and cash equivalents, end of period 26,707 34,487
Cash received during the period for:    
Interest 5 9
Taxes 1,811 970
Schedule of non-cash transactions:    
Issuance of Ordinary shares in lieu of cash bonus   $ 181