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Stock-Based Compensation Arrangements (Tables)

12 Months Ended

Dec. 31, 2014

Stock-Based Compensation Arrangements

Schedule of stock based compensation expense

		Year Ended December 31, 2013				Year Ended December 31, 2014
Research and development		$	75			$	392
General and administrative			282				831
Stock-based compensation costs before income taxes		$	357			$	1,223

Schedule of stock option activity

		Number of Options Outstanding				Weighted Average Exercise Price Per Share				Weighted Average Remaining Contractual Term (Years)				Aggregate Intrinsic Value ($000s)
Options outstanding at December 31, 2012			463,023			$	26.61				5.58			$	347
Granted			494,663			$	4.22
Exercised			—
Cancelled/forfeited			(8,001	)		$	18.55
Options outstanding at December 31, 2013			949,685			$	15.02				7.38			$	152
Granted			63,000			$	3.11
Exercised			—
Cancelled/forfeited			(2,387	)		$	31.08
Options outstanding at December 31, 2014			1,010,298			$	14.24				6.58			$	—
Unvested at December 31, 2014			402,900			$	4.07				8.95			$	—
Vested and exercisable at December 31, 2014			607,395			$	20.99				5.00			$	—

Schedule of assumptions for stock option grants to employees and directors

		Year ended December 31, 2013		Year ended December 31, 2014
Expected term (years)		5 —6		6
Risk free interest rate		0.84% - 1.865%		1.835% - 2.005%
Volatility		97—108%		101%
Expected dividend yield over expected term		0.00%		0.00%
Resulting weighted average grant date fair value		$3.25		$2.48

Schedule of restricted stock units activity

		Restricted Stock Units				Weighted Average Grant Date Value Per Share
Non-vested at December 31, 2012			39,377			$	5.34
Granted			85,097			$	5.71
Forfeited			(5,226	)		$	5.00
Non-vested at December 31, 2013			119,248			$	5.62
Granted			—			$	—
Vested			(29,999	)		$	5.81
Forfeited			(233	)		$	5.39
Non-vested at December 31, 2014			89,016			$	5.56

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Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

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Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year.

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Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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