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CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2015
Jun. 30, 2014
Operating activities:    
Net loss $ (8,259) $ (9,681)
Change in valuation of liabilities measured at fair value   (20)
Change in valuation of financial instruments associated with stock purchase agreement 24 111
Depreciation 102 46
Stock-based compensation 323 370
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 1,198 34
Accounts payable and other current liabilities (1,066) 313
Net cash used in operating activities (7,678) (8,827)
Investing activities:    
Purchase of property, plant and equipment (22) (65)
Minimum royalty payments received from termination of ALIGN license agreement 23 192
Net cash provided by investing activities 1 127
Financing activities:    
Proceeds from issuance of common stock, net of issuance costs 10,356 10,965
Payment of preferred stock dividend (100) (100)
Net cash provided by financing activities 10,256 10,865
Effect of exchange rate changes on cash and cash equivalents 134 145
Net increase in cash and cash equivalents 2,713 2,310
Cash and cash equivalents, beginning of period 24,189 31,146
Cash and cash equivalents, end of period 26,902 33,456
Cash received during the period for:    
Interest 3 3
Taxes $ 2,875 $ 1,811