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CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Operating activities:    
Net loss $ (10,968) $ (14,588)
Adjustments to reconcile net loss to net cash used in operating activities:    
Change in valuation of liabilities measured at fair value   (20)
Change in valuation of financial instruments associated with stock purchase agreement 51 115
Depreciation 157 115
Stock-based compensation 464 589
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 583 (842)
Accounts payable and other current liabilities (2,071) (403)
Net cash used in operating activities (11,784) (15,034)
Investing activities:    
Purchase of property, plant and equipment (32) (302)
Minimum royalty payments received from termination of ALIGN license agreement 23 288
Net cash used in investing activities (9) (14)
Financing activities:    
Proceeds from issuance of common stock, net of issuance costs 10,576 10,965
Payment of preferred stock dividend (150) (150)
Net cash provided by financing activities 10,426 10,815
Effect of exchange rate changes on cash and cash equivalents (94) (206)
Net decrease in cash and cash equivalents (1,461) (4,439)
Cash and cash equivalents, beginning of period 24,189 31,146
Cash and cash equivalents, end of period 22,728 26,707
Cash received during the period for:    
Interest 6 5
Taxes $ 2,875 $ 1,811