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Property, Plant and Equipment (Tables)
 12 Months Ended
Dec. 31, 2015
Property, Plant and Equipment  
Schedule of property, plant and equipment
​ ​ ​
Useful lives in years from 
date of acquisition
 ​ ​
December 31,
 ​
​ ​ ​
2014
 ​ ​
2015
 ​
Leasehold improvements
 ​ ​
5 to 15 years
 ​ ​ ​ $ 914 ​ ​ ​ ​ $ 885 ​ ​
Research and laboratory equipment
 ​ ​
3 to 5 years
 ​ ​ ​ ​ 5,881 ​ ​ ​ ​ ​ 5,604 ​ ​
Office equipment and furniture
 ​ ​
3 to 5 years
 ​ ​ ​ ​ 1,302 ​ ​ ​ ​ ​ 1,294 ​ ​
​ ​ ​ ​ ​ ​ ​ ​ 8,097 ​ ​ ​ ​ ​ 7,783 ​ ​
Less: accumulated depreciation and amortization
 ​ ​ ​ ​ ​ ​ ​ (7,710) ​ ​ ​ ​ ​ (7,585) ​ ​
​ ​ ​ ​ ​ ​ ​ $ 387 ​ ​ ​ ​ $ 198 ​ ​
​