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Property, Plant and Equipment (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Property, plant and equipment    
Property, plant and equipment, gross $ 7,783 $ 8,097
Less: accumulated depreciation and amortization (7,585) (7,710)
Property, Plant and Equipment, Net 198 387
Leasehold improvements    
Property, plant and equipment    
Property, plant and equipment, gross $ 885 914
Leasehold improvements | Minimum    
Property, plant and equipment    
Useful lives in years from date of acquisition 5 years  
Leasehold improvements | Maximum    
Property, plant and equipment    
Useful lives in years from date of acquisition 15 years  
Research and laboratory equipment    
Property, plant and equipment    
Property, plant and equipment, gross $ 5,604 5,881
Research and laboratory equipment | Minimum    
Property, plant and equipment    
Useful lives in years from date of acquisition 3 years  
Research and laboratory equipment | Maximum    
Property, plant and equipment    
Useful lives in years from date of acquisition 5 years  
Office equipment and furniture    
Property, plant and equipment    
Property, plant and equipment, gross $ 1,294 $ 1,302
Office equipment and furniture | Minimum    
Property, plant and equipment    
Useful lives in years from date of acquisition 3 years  
Office equipment and furniture | Maximum    
Property, plant and equipment    
Useful lives in years from date of acquisition 5 years