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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Operating activities:    
Net loss $ (14,342) $ (19,387)
Change in valuation of liabilities at fair value   (20)
Change in valuation of financial instruments associated with stock purchase agreement 51 342
Depreciation 210 174
Stock-based compensation 745 1,223
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 342 (1,700)
Accounts payable and other current liabilities (1,466) 666
Net cash used in operating activities (14,460) (18,702)
Investing activities:    
Purchase of property, plant and equipment (34) (309)
Minimum royalty payments received from termination of ALIGN license agreement 96 384
Net cash provided by investing activities 62 75
Financing activities:    
Proceeds from issuance of common stock and warrants, net of issuance costs 11,061 12,421
Proceeds from the exercise of stock options and warrants, net of issuance costs   (21)
Payment of preferred stock dividend (201) (200)
Net cash provided by financing activities 10,860 12,200
Effect of exchange rate changes on cash and cash equivalents (211) (530)
Net decrease in cash and cash equivalents (3,749) (6,957)
Cash and cash equivalents, beginning of period 24,189 31,146
Cash and cash equivalents, end of period 20,440 24,189
Cash received during the period for:    
Interest 10 6
Taxes 2,861 1,811
Cash flow from discontinued operations:    
Net cash provided by investing activities 96 384
Non cash financing activities:    
Accrual of preferred stock dividends $ 50 $ 50