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CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Operating activities:    
Net loss $ (3,041) $ (4,912)
Adjustments to reconcile net loss to net cash used in operating activities:    
Change in valuation of financial instruments associated with stock purchase agreement   20
Depreciation 42 52
Stock-based compensation 221 164
Changes in operating assets and liabilities:    
Prepaid expenses and other assets (182) (1,111)
Accounts payable and other current liabilities (187) 887
Net cash used in operating activities (3,147) (4,900)
Investing activities:    
Purchase of property, plant and equipment   (14)
Minimum royalty payments received from termination of ALIGN license agreement   23
Net cash used in investing activities   9
Financing activities:    
Proceeds from issuance of common stock, net of issuance costs   10,433
Payment of preferred stock dividend (50) (50)
Net cash provided by financing activities (50) 10,383
Effect of exchange rate changes on cash and cash equivalents (128) (318)
Net increase / (decrease) in cash and cash equivalents (3,325) 5,174
Cash and cash equivalents, beginning of period 20,440 24,189
Cash and cash equivalents, end of period 17,115 29,363
Cash received during the period for:    
Interest   1
Non cash financing activities:    
Accrual of preferred stock dividends $ 50 $ 50