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CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Operating activities:    
Net loss $ (8,952) $ (10,968)
Adjustments to reconcile net loss to net cash used in operating activities:    
Change in valuation of financial instruments associated with stock purchase agreement   51
Depreciation 109 157
Stock-based compensation 614 464
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 629 583
Accounts payable and other current liabilities 464 (2,071)
Net cash used in operating activities (7,136) (11,784)
Investing activities:    
Purchase of property, plant and equipment   (32)
Minimum royalty payments received from termination of ALIGN license agreement   23
Net cash used in investing activities   (9)
Financing activities:    
Proceeds from issuance of common stock, net of issuance costs 5,241 10,576
Payment of preferred stock dividend (150) (150)
Net cash provided by financing activities 5,091 10,426
Effect of exchange rate changes on cash and cash equivalents (366) (94)
Net decrease in cash and cash equivalents (2,411) (1,461)
Cash and cash equivalents, beginning of period 20,440 24,189
Cash and cash equivalents, end of period 18,029 22,728
Cash received during the period for:    
Interest 31 6
Taxes 1,965 2,875
Non cash financing activities:    
Accrual of preferred stock dividends 50 $ 50
Receivable from issuance of common stock $ 1,518