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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015
Cash flows from operating activities: |  |
Net loss | $ (11,791) | $ (14,342)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Change in valuation of financial instruments associated with stock purchase agreement |  | 51
Depreciation expense | 133 | 210
Gain on disposal of property and equipment | (12) |
Stock-based compensation expense | 782 | 745
Changes in operating assets and liabilities: |  |
Prepaid expenses and other assets | 439 | 342
Accounts payable and other current liabilities | 370 | (1,466)
Net cash used in operating activities | (10,079) | (14,460)
Cash flows from investing activities: |  |
Purchases of property and equipment | (3) | (34)
Proceeds from sale of property and equipment | 12 |
Minimum royalty payments received from termination of ALIGN license agreement |  | 96
Net cash provided by investing activities | 9 | 62
Cash flows from financing activities: |  |
Proceeds from issuance of common stock, net of issuance costs | 6,794 | 11,061
Payment of preferred stock dividend | (200) | (201)
Net cash provided by financing activities | 6,594 | 10,860
Effect of exchange rate changes on cash and cash equivalents | (444) | (211)
Net decrease in cash and cash equivalents | (3,920) | (3,749)
Cash and cash equivalents at beginning of period | 20,440 | 24,189
Cash and cash equivalents at end of period | 16,520 | 20,440
Cash received during the period for: |  |
Interest | 38 | 10
Taxes | 1,965 | 2,861
Non cash financing activities: |  |
Accrual of preferred stock dividends | $ 50 | $ 50

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- Definition Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Excludes cash and cash equivalents within disposal group and discontinued operation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Cash -URI http://asc.fasb.org/extlink&oid=6506951 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=28358313&loc=d3e6676-107765 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3044-108585 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Cash Equivalents -URI http://asc.fasb.org/extlink&oid=6507016 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.1) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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