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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2016
Stock-Based Compensation Arrangements |
Schedule of stock based compensation expense |
|  |  | Year Ended December 31, |
|  |  | 2015 |  |  | 2016 |
Research and development |  |  |  | $ | 240 |  |  |  |  | $ | 305 |  |
General and administrative |  |  |  |  | 505 |  |  |  |  |  | 477 |  |
Total |  |  |  | $ | 745 |  |  |  |  | $ | 782 |  |
Schedule of stock option activity |
​ | ​ | ​ | Number of Options Outstanding | ​ | ​ | Weighted Average Exercise Price Per Share | ​ | ​ | Weighted Average Remaining Life in Years | ​ | ​ | Aggregate Intrinsic Value
Options outstanding at December 31, 2014 | ​ | ​ | ​ | ​ | 84,192 | ​ | ​ | ​ | ​ | $ | 170.88 | ​ | ​ | ​ | ​ | ​ | 6.58 | ​ | ​ | ​ | ​ | $ | —
Granted | ​ | ​ | ​ | ​ | 122,523 | ​ | ​ | ​ | ​ | $ | 7.60 | ​ | ​ | ​ | ​
Exercised | ​ | ​ | ​ | ​ | — | ​ | ​ | ​ | ​ | $ | — | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Cancelled/forfeited | ​ | ​ | ​ | ​ | (417) | ​ | ​ | ​ | ​ | $ | 813.84 | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Options Outstanding at December 31, 2015 | ​ | ​ | ​ | ​ | 206,298 | ​ | ​ | ​ | ​ | $ | 72.60 | ​ | ​ | ​ | ​ | ​ | 8.09 | ​ | ​ | ​ | ​ | $ | —
Granted | ​ | ​ | ​ | ​ | 197,841 | ​ | ​ | ​ | ​ | $ | 4.68 | ​ | ​ | ​ | ​
Exercised | ​ | ​ | ​ | ​ | — | ​ | ​ | ​ | ​ | $ | — | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Cancelled/forfeited | ​ | ​ | ​ | ​ | (14,761) | ​ | ​ | ​ | ​ | $ | 396.83 | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Options Outstanding at December 31, 2016 | ​ | ​ | ​ | ​ | 389,378 | ​ | ​ | ​ | ​ | $ | 25.80 | ​ | ​ | ​ | ​ | ​ | 5.83 | ​ | ​ | ​ | ​ | $ | 121.40
Unvested at December 31, 2016 | ​ | ​ | ​ | ​ | (267,582) | ​ | ​ | ​ | ​ | $ | 5.37 | ​ | ​ | ​ | ​ | ​ | 5.44 | ​ | ​ | ​ | ​ | $ | 121.40
Vested and exercisable at December 31, 2016 | ​ | ​ | ​ | ​ | 121,796 | ​ | ​ | ​ | ​ | $ | 70.67 | ​ | ​ | ​ | ​ | ​ | 6.68 | ​ | ​ | ​ | ​ | $ | —
​
Schedule of assumptions for stock option grants to employees and directors |
|  |  | Year Ended December 31, |
|  |  | 2015 |  |  | 2016 |
Expected term (in years) |  |  | 5 – 6 |  |  | 5 – 6 |
Risk-free interest rate |  |  | 1.52% – 1.845% |  |  | 1.37% – 1.50% |
Volatility |  |  | 96% – 108% |  |  | 98% – 104% |
Expected dividend yield over expected term |  |  | 0.00% |  |  | 0.00% |
Resulting weighted average grant date fair value |  |  | $6.16 |  |  | $3.66 |

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