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Property and Equipment (Tables)
12 Months Ended
Dec. 31, 2016
Property, Plant and Equipment  
Schedule of property and equipment
     
Lives in years
   
December 31,
 
     
2015
   
2016
 
Leasehold improvements
   
5 to 15 
      $ 885         $ 792    
Research and laboratory equipment
   
3 to 5 
        5,604           4,438    
Office equipment and furniture
   
3 to 5 
        1,294           1,157    
                7,783           6,387    
Less: accumulated depreciation and amortization
              (7,585)           (6,342)    
                198           45