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Property, Plant and Equipment (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Property, plant and equipment    
Property, plant and equipment, gross $ 6,387 $ 7,783
Less: accumulated depreciation and amortization (6,342) (7,585)
Property, Plant and Equipment, Net 45 198
Leasehold improvements    
Property, plant and equipment    
Property, plant and equipment, gross $ 792 885
Leasehold improvements | Minimum    
Property, plant and equipment    
Lives in years 5 years  
Leasehold improvements | Maximum    
Property, plant and equipment    
Lives in years 15 years  
Research and laboratory equipment    
Property, plant and equipment    
Property, plant and equipment, gross $ 4,438 5,604
Research and laboratory equipment | Minimum    
Property, plant and equipment    
Lives in years 3 years  
Research and laboratory equipment | Maximum    
Property, plant and equipment    
Lives in years 5 years  
Office equipment and furniture    
Property, plant and equipment    
Property, plant and equipment, gross $ 1,157 $ 1,294
Office equipment and furniture | Minimum    
Property, plant and equipment    
Lives in years 3 years  
Office equipment and furniture | Maximum    
Property, plant and equipment    
Lives in years 5 years