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Stock-Based Compensation Arrangements (Details 1) - Stock options - USD ($)
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Number of Options Outstanding      
Options outstanding at the beginning of the period (in shares) 206,298 84,192  
Granted (in shares) 197,841 122,523  
Exercised (in shares)  
Cancelled / forfeited (in shares) (14,761) (417)  
Options outstanding at the end of the period (in shares) 389,378 206,298 84,192
Unvested at December 31, 2016 (267,582)    
Vested and exercisable at December 31, 2016 121,796    
Weighted Average Exercise Price Per Share      
Options outstanding at the beginning of the period (in dollars per share) $ 72.60 $ 170.88  
Granted (in dollars per share) 4.68 7.60  
Cancelled / forfeited (in dollars per share) 396.83 813.84  
Options outstanding at the end of the period (in dollars per share) 25.80 $ 72.60 $ 170.88
Unvested at the end of the period (in dollars per share) 5.37    
Vested and exercisable at the end of the period (in dollars per share) $ 70.67    
Weighted Average Remaining Contractual Term (Years)      
Options outstanding 5 years 9 months 29 days 8 years 1 month 2 days 6 years 6 months 29 days
Unvested at the end of the period 5 years 5 months 9 days    
Vested and exercisable at the end of the period 6 years 8 months 5 days    
Aggregate Intrinsic Value      
Options outstanding $ 121.40    
Unvested at the end of the period 121.40    
Vested and exercisable at the end of the period