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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Cash flows from operating activities:    
Net loss $ (11,791) $ (14,342)
Adjustments to reconcile net loss to net cash used in operating activities:    
Change in valuation of financial instruments associated with stock purchase agreement   51
Depreciation expense 133 210
Gain on disposal of property and equipment (12)  
Stock-based compensation expense 782 745
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 439 342
Accounts payable and other current liabilities 370 (1,466)
Net cash used in operating activities (10,079) (14,460)
Cash flows from investing activities:    
Purchases of property and equipment (3) (34)
Proceeds from sale of property and equipment 12  
Minimum royalty payments received from termination of ALIGN license agreement   96
Net cash provided by investing activities 9 62
Cash flows from financing activities:    
Proceeds from issuance of common stock, net of issuance costs 6,794 11,061
Payment of preferred stock dividend (200) (201)
Net cash provided by financing activities 6,594 10,860
Effect of exchange rate changes on cash and cash equivalents (444) (211)
Net decrease in cash and cash equivalents (3,920) (3,749)
Cash and cash equivalents at beginning of period 20,440 24,189
Cash and cash equivalents at end of period 16,520 20,440
Cash received during the period for:    
Interest 38 10
Taxes 1,965 2,861
Non cash financing activities:    
Accrual of preferred stock dividends $ 50 $ 50