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Stock Based Compensation (Tables)
 6 Months Ended
Jun. 30, 2017
Disclosure Of Compensation Related Costs Share-Based Payments [Abstract]  
Schedule of stock based compensation expense
  Three Months Ended
June 30,		  Six Months Ended
June 30,		 
  2016  2017  2016  2017 
General and administrative $120  $49  $262  $99 
Research and development  79   17   158   36 
Stock-based compensation costs before income taxes $199  $66  $420  $135 
Schedule of share option activity
    Number of
Options
Outstanding		     Weighted
Average
Exercise
Price Per Share		     Weighted
Average
Remaining
Contractual
Term (Years)		     Aggregate
Intrinsic
Value ($000)		  
Options outstanding at December 31, 2016     389,379     $ 25.80       5.83     $ 121  
Granted     12,000     $ 4.38                  
Cancelled/forfeited     (18,529 )   $ 89.95                  
Options outstanding at June 30, 2017     382,850     $ 22.02       5.48     $ —  
Unvested at June 30, 2017     (245,915 )   $ 5.15       4.79     $ —  
Vested and exercisable at June 30, 2017     136,935     $ 52.32       6.70     $ —