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Stock Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2017
Disclosure Of Compensation Related Costs Share-Based Payments [Abstract]  
Schedule of stock based compensation expense
    Three Months Ended
September 30,		     Nine Months Ended
September 30,		  
    2016     2017     2016     2017  
General and administrative   $ 113     $ 48     $ 376     $ 146  
Research and development     79       17       238       54  
Stock-based compensation costs before income taxes   $ 192     $ 65     $ 614     $ 200  
Schedule of share option activity
    Number of
Options
Outstanding		     Weighted
Average
Exercise
Price Per Share		     Weighted
Average
Remaining
Contractual
Term (Years)		     Aggregate
Intrinsic
Value ($000)		  
Options outstanding at December 31, 2016     389,379     $ 25.80       5.83     $ 121  
Granted     12,000     $ 4.38                  
Cancelled/forfeited     (19,593 )   $ 108.73                  
Options outstanding at September 30, 2017     381,786     $ 20.87       5.24     $ —  
Unvested at September 30, 2017     (236,962 )   $ 5.06       4.41     $ —  
Vested and exercisable at September 30, 2017     144,824     $ 46.73       6.60     $ —