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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2017
Stock-Based Compensation Arrangements |
Schedule of stock based compensation expense |
|  |  | Year Ended December 31, 2016 |  |  | Year Ended December 31, 2017 |
Research and development |  |  |  | $ | 305 |  |  |  |  | $ | 72 |  |
General and administrative |  |  |  |  | 477 |  |  |  |  |  | 194 |  |
Stock-based compensation costs before income taxes |  |  |  | $ | 782 |  |  |  |  | $ | 266 |  |
Schedule of stock option activity |
|  |  | Number of Options Outstanding |  |  | Weighted Average Exercise Price Per Share |  |  | Weighted Average Remaining Contractual Term (Years) |  |  | Aggregate Intrinsic Value ($000s) |
Options outstanding at December 31, 2015 |  |  |  |  | 206,298 |  |  |  |  | $ | 72.60 |  |  |  |  |  | 8.09 |  |  |  |  | $ | — |  |
Granted |  |  |  |  | 197,841 |  |  |  |  | $ | 4.68 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercised |  |  |  |  | — |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cancelled/forfeited |  |  |  |  | (14,760) |  |  |  |  | $ | 396.83 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options outstanding at December 31, 2016 |  |  |  |  | 389,379 |  |  |  |  | $ | 25.80 |  |  |  |  |  | 5.83 |  |  |  |  | $ | 121 |  |
Granted |  |  |  |  | 170,853 |  |  |  |  | $ | 1.93 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercised |  |  |  |  | — |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cancelled/forfeited |  |  |  |  | (24,615) |  |  |  |  | $ | 179.92 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options outstanding at December 31, 2017 |  |  |  |  | 535,617 |  |  |  |  | $ | 11.10 |  |  |  |  |  | 8.23 |  |  |  |  | $ | — |  |
Unvested at December 31, 2017 |  |  |  |  | 386,682 |  |  |  |  | $ | 3.64 |  |  |  |  |  | 8.84 |  |  |  |  | $ | — |  |
Vested and exercisable at December 31, 2017 |  |  |  |  | 148,755 |  |  |  |  | $ | 30.49 |  |  |  |  |  | 6.65 |  |  |  |  | $ | — |  |
Schedule of fair value of the stock options granted |
|  |  | Year ended December 31, 2016 |  |  | Year ended December 31, 2017 |
Expected term (years) |  |  | 5 – 6 |  |  | 6 |
Risk free interest rate |  |  | 1.370% – 1.500% |  |  | 1.890% – 2.265% |
Volatility |  |  | 98% – 104% |  |  | 108% |
Expected dividend yield over expected term |  |  | 0.00% |  |  | 0.00% |
Resulting weighted average grant date fair value |  |  | $3.66 |  |  | $1.59 |

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