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Property and Equipment (Tables)
12 Months Ended
Dec. 31, 2017
Property, Plant and Equipment  
Schedule of property and equipment
     
Lives in years
   
December 31,
 
     
2016
   
2017
 
Leasehold improvements
   
5 to 15 
      $ 792         $ 835    
Research and laboratory equipment
   
3 to 5 
        4,438           4,854    
Office equipment and furniture
   
3 to 5 
        1,157           1,236    
                6,387           6,925    
Less: accumulated depreciation and amortization
              (6,342)           (6,896)    
              45         29