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Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2017

Stock-Based Compensation Arrangements

Schedule of stock based compensation expense

			Year Ended  December 31,  2016						Year Ended  December 31,  2017
Research and development				$	305					$	72
General and administrative					477						194
Stock-based compensation costs before income taxes				$	782					$	266

Schedule of stock option activity

			Number of  Options  Outstanding						Weighted  Average  Exercise Price  Per Share						Weighted  Average  Remaining  Contractual  Term (Years)						Aggregate  Intrinsic  Value ($000s)
Options outstanding at December 31, 2015					206,298					$	72.60						8.09					$	—
Granted					197,841					$	4.68
Exercised					—
Cancelled/forfeited					(14,760)					$	396.83
Options outstanding at December 31, 2016					389,379					$	25.80						5.83					$	121
Granted					170,853					$	1.93
Exercised					—
Cancelled/forfeited					(24,615)					$	179.92
Options outstanding at December 31, 2017					535,617					$	11.10						8.23					$	—
Unvested at December 31, 2017					386,682					$	3.64						8.84					$	—
Vested and exercisable at December 31, 2017					148,755					$	30.49						6.65					$	—

Schedule of fair value of the stock options granted

			Year ended  December 31, 2016			Year ended  December 31, 2017
Expected term (years)			5 – 6			6
Risk free interest rate			1.370% – 1.500%			1.890% – 2.265%
Volatility			98% – 104%			108%
Expected dividend yield over expected term			0.00%			0.00%
Resulting weighted average grant date fair value			$3.66			$1.59

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Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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