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Organization of the Company and Basis of Presentation (Detail Textuals) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
May 27, 2016
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Organization of the Company        
Net loss   $ (7,470) $ (11,791)  
Accumulated deficit   (342,509) (335,039)  
Cash and cash equivalents   $ 23,910 $ 16,520 $ 20,440
Stockholders' equity, reverse stock split one-for-twelve      
Common stock, par value (in dollars per share)   $ 0.001 $ 0.001