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Stock-Based Compensation Arrangements (Details 1) - Stock options - USD ($)
$ / shares in Units, $ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Number of Options Outstanding      
Options outstanding at the beginning of the period (in shares) 389,379 206,298  
Granted (in shares) 170,853 197,841  
Exercised (in shares) 0 0  
Cancelled / forfeited (in shares) (24,615) (14,760)  
Options outstanding at the end of the period (in shares) 535,617 389,379 206,298
Unvested at December 31, 2017 386,682    
Vested and exercisable at December 31, 2017 148,755    
Weighted Average Exercise Price Per Share      
Options outstanding at the beginning of the period (in dollars per share) $ 25.80 $ 72.60  
Granted (in dollars per share) 1.93 4.68  
Cancelled / forfeited (in dollars per share) 179.92 396.83  
Options outstanding at the end of the period (in dollars per share) 11.10 $ 25.80 $ 72.60
Unvested at the end of the period (in dollars per share) 3.64    
Vested and exercisable at the end of the period (in dollars per share) $ 30.49    
Weighted Average Remaining Contractual Term (Years)      
Options outstanding 8 years 2 months 23 days 5 years 9 months 29 days 8 years 1 month 2 days
Unvested at the end of the period 8 years 10 months 2 days    
Vested and exercisable at the end of the period 6 years 7 months 24 days    
Aggregate Intrinsic Value      
Options outstanding   $ 121