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Stock Based Compensation (Tables)
3 Months Ended
Mar. 31, 2018
Disclosure Of Compensation Related Costs Share-Based Payments [Abstract]  
Schedule of stock based compensation expense
    Three Months Ended
March 31,
 
    2017     2018  
General and administrative   $ 50     $ 59  
Research and development     19       22  
Stock-based compensation costs before income taxes   $ 69     $ 81  
Schedule of share option activity
    Number of Options
Outstanding
    Weighted Average
Exercise
Price Per Share
    Weighted
Average
Remaining
Contractual
Term (Years)
    Aggregate
Intrinsic
Value ($000)
 
Options outstanding at December 31, 2017     535,617     $ 11.10       8.23     $  
Granted     174,272     $ 1.56                  
Cancelled/forfeited     (1,488 )   $ 362.04                  
Options outstanding at March 31, 2018     708,401     $ 8.02       8.47     $  
Unvested at March 31, 2018     (552,654 )   $ 2.93       9.02     $  
Vested and exercisable at March 31, 2018     155,748     $ 26.06       6.53     $